Amines REACH

Cyclopropylamine

CAS Number
765-30-0
EC Number
212-142-2
Abbreviation
CPA

What is Cyclopropylamine?

Cyclopropylamine (CAS 765-30-0) is a strained-ring primary amine used as a reactive building block in pharmaceutical synthesis and specialty polymer chemistry. Also known as CPA.

Where is Cyclopropylamine used?

  • Pharmaceutical manufacturing: incorporated into active pharmaceutical ingredient synthesis
  • Preparation of kinase inhibitors, antidepressants and other small-molecule drug candidates where the cyclopropyl motif improves metabolic stability
  • Polymer chemistry: curing agent and cross-linker in epoxy and specialty resin systems, where controlled amine reactivity influences network density and mechanical performance
  • Agrochemical development: key intermediate for herbicide synthesis
  • Biotech research: building block for probe compounds and enzyme inhibitors in target-based drug discovery
  • It is a valued intermediate for constructing complex molecular architectures at scale.

Commercial specifications

  • Technical and high-purity grades; purity typically 98% up to 99%+ for pharmaceutical intermediate use
  • Packaging from small research quantities to bulk drums and IBC containers

Other Names (Synonyms)

8PR8XTH1X1|RefChem:581232|CPA

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What are the physical properties of Cyclopropylamine?

Melting Point -35.4 °C
Boiling Point 49-50 °C
Density 0.824 g/mL at 25 °C(lit.)
Flash Point −14 °F
Appearance clear colorless to very slightly yellow liquid
Color Clear colorless
Form Volatile Liquid
Water Solubility Miscible with water, ethanol,ether and chloroform.
Vapor Pressure 4.67 psi ( 20 °C)
Refractive Index n 20/D 1.420(lit.)
Log P 0.070

How is Cyclopropylamine classified and handled safely? Learn More

Danger
GHS02· Flammable GHS05· Corrosive GHS07· Irritant

Hazard Statements

H225 Highly Flammable liquid and vapor
H302 Harmful if swallowed
H314 Causes severe skin burns and eye damage
H317 May cause an allergic skin reaction

Precautionary Statements

P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
P233 Keep container tightly closed.
P240 Ground and bond container and receiving equipment.
P241 Use explosion-proof [electrical/ventilating/lighting/…] equipment.

Which trade and regulatory codes apply to Cyclopropylamine?

HS Code 29213099
UN Number 2733
ADR Class 3
Packing Group II
WGK (Germany) 2
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