Amines REACH

n-methylpiperazine

CAS Number
109-01-3
EC Number
203-639-5

What is n-methylpiperazine?

N-Methylpiperazine (CAS 109-01-3) is a cyclic diamine building block used in pharmaceutical synthesis, polymer chemistry and industrial process chemistry.

Where is n-methylpiperazine used?

  • Pharmaceutical manufacturing: structural component in synthesis of active pharmaceutical ingredients, including antipsychotics, antivirals and antibiotics where the piperazine ring is incorporated
  • Polymer and epoxy systems: curing agent and cross-linker, where controlled reactivity with epoxide groups influences network density and mechanical properties
  • Water treatment: biocide intermediate and corrosion inhibitor precursor for formulations controlling microbial growth in cooling and process water
  • Catalyst production: ligand precursor and amine catalyst in polyurethane and specialty polymer manufacturing
  • Its secondary and tertiary amine groups make it a reactive intermediate for constructing drug molecules.

Commercial specifications

  • Purity typically 98% to 99%+ depending on application
  • Colorless to pale yellow liquid in drum and IBC quantities, with bulk tanker options

Other Names (Synonyms)

1-methylpiperazine|PIPERAZINE, 1-METHYL-|B92I95EL9Q|RefChem:434645

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What are the physical properties of n-methylpiperazine?

Melting Point -6 °C
Boiling Point 138 °C
Density 0.88607 g/cm³ @ Temp: 40.00 °C
Flash Point 108 °F
Appearance clear liquid
Color Clear
Form Liquid
Water Solubility soluble
Vapor Pressure 12 hPa (20 °C)
Refractive Index n 20/D 1.466(lit.)
pH 11-12 (50g/l, H2O, 20℃)
Log P -0.57 at 25℃

How is n-methylpiperazine classified and handled safely? Learn More

Danger
GHS02· Flammable GHS05· Corrosive GHS06· Toxic GHS07· Irritant

Hazard Statements

H226 Flammable liquid and vapor
H312 Harmful in contact with skin
H314 Causes severe skin burns and eye damage
H317 May cause an allergic skin reaction

Precautionary Statements

P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
P233 Keep container tightly closed.
P240 Ground and bond container and receiving equipment.
P241 Use explosion-proof [electrical/ventilating/lighting/…] equipment.

Which trade and regulatory codes apply to n-methylpiperazine?

HS Code 29335995
UN Number 2734
ADR Class 8
Packing Group II
Storage Class 3 - Flammable liquids
WGK (Germany) 2
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