Amines REACH

n-methylpiperazine

CAS Number
109-01-3
EC Number
203-639-5
Chemical Formula
C5H12N2
Molecular Weight
100.16 g/mol

Description

N-Methylpiperazine (CAS 109-01-3) is a cyclic diamine building block used across pharmaceutical synthesis, polymer chemistry, and industrial process chemistry. Its secondary and tertiary amine groups make it a reactive intermediate for constructing drug molecules. In pharmaceutical manufacturing, it serves as a key structural component in the synthesis of active pharmaceutical ingredients, including several antipsychotics, antivirals, and antibiotics where the piperazine ring is incorporated.

Polymer and epoxy formulators use it as a curing agent and cross-linker, where controlled reactivity with epoxide groups influences network density and final mechanical properties in industrial applications. In water treatment, it functions as a biocide intermediate and corrosion inhibitor precursor, contributing to formulations that control microbial growth in industrial cooling and process water systems.

Catalyst manufacturers also use it as a ligand precursor and amine catalyst in polyurethane and specialty polymer production, providing essential functionality for high-performance chemical manufacturing. N-Methylpiperazine is supplied as a colorless to pale yellow liquid in drum and IBC quantities, with bulk tanker options available for high-volume industrial buyers requiring consistent supply chains.

Standard commercial grades include technical grade and pharmaceutical-grade material meeting specifications relevant to API intermediate production. Purity levels typically range from 98% to 99%+ depending on the application.

Other Names (Synonyms)

1-methylpiperazine|PIPERAZINE, 1-METHYL-|B92I95EL9Q|RefChem:434645

Key Technical Features

  • High Purity Grade standard
  • Consistent Batch Quality
  • Full Regulatory & REACH Support
  • Global Logistics Network enabled

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Physical Properties

Melting Point -6 °C
Boiling Point 138 °C
Density 0.88607 g/cm³ @ Temp: 40.00 °C
Flash Point 108 °F
Appearance clear liquid
Color Clear
Form Liquid
Water Solubility soluble
Vapor Pressure 12 hPa (20 °C)
Refractive Index n 20/D 1.466(lit.)
pH 11-12 (50g/l, H2O, 20℃)
Log P -0.57 at 25℃

Documentation

Safety & Handling Learn More

Danger
GHS02· Flammable GHS05· Corrosive GHS06· Toxic GHS07· Irritant

Hazard Statements

H226 Flammable liquid and vapor
H312 Harmful in contact with skin
H314 Causes severe skin burns and eye damage
H317 May cause an allergic skin reaction

Precautionary Statements

P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
P233 Keep container tightly closed.
P240 Ground and bond container and receiving equipment.
P241 Use explosion-proof [electrical/ventilating/lighting/…] equipment.

Trade & Regulatory

HS Code 29335995
UN Number 2734
ADR Class 8
Packing Group II
Storage Class 3 - Flammable liquids
WGK (Germany) 2
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