n-methylpiperazine
Description
N-Methylpiperazine (CAS 109-01-3) is a cyclic diamine building block used across pharmaceutical synthesis, polymer chemistry, and industrial process chemistry. Its secondary and tertiary amine groups make it a reactive intermediate for constructing drug molecules.
In pharmaceutical manufacturing, it serves as a key structural component in the synthesis of active pharmaceutical ingredients, including several antipsychotics, antivirals, and antibiotics where the piperazine ring is incorporated.
Polymer and epoxy formulators use it as a curing agent and cross-linker, where controlled reactivity with epoxide groups influences network density and final mechanical properties in industrial applications.
In water treatment, it functions as a biocide intermediate and corrosion inhibitor precursor, contributing to formulations that control microbial growth in industrial cooling and process water systems.
Catalyst manufacturers also use it as a ligand precursor and amine catalyst in polyurethane and specialty polymer production, providing essential functionality for high-performance chemical manufacturing.
N-Methylpiperazine is supplied as a colorless to pale yellow liquid in drum and IBC quantities, with bulk tanker options available for high-volume industrial buyers requiring consistent supply chains.
Standard commercial grades include technical grade and pharmaceutical-grade material meeting specifications relevant to API intermediate production. Purity levels typically range from 98% to 99%+ depending on the application.
Physical Properties
| Melting Point | -6 °C |
| Boiling Point | 138 °C |
| Density | 0.88607 g/cm³ @ Temp: 40.00 °C |
| Flash Point | 108 °F |
| Appearance | clear liquid |
| Color | Clear |
| Form | Liquid |
| Water Solubility | soluble |
| Vapor Pressure | 12 hPa (20 °C) |
| Refractive Index | n 20/D 1.466(lit.) |
| pH | 11-12 (50g/l, H2O, 20℃) |
| Log P | -0.57 at 25℃ |
Safety & Handling (Learn More)
Trade & Regulatory
| HS Code | 29335995 |
| UN Number | 2734 |
| ADR Class | 8 |
| Packing Group | II |
| Storage Class | 3 - Flammable liquids |
| WGK (Germany) | 2 |
Documentation
Other Names
1-methylpiperazine|PIPERAZINE, 1-METHYL-|B92I95EL9Q|RefChem:434645
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