SoleChem

1-(2-Dimethylaminoethyl)piperazine

CAS
3644-18-6
EC
628-996-8
Mol. Weight
157.26 g/mol

Description

1-(2-Dimethylaminoethyl)piperazine (CAS 3644-18-6), also known commercially as TAP, is a bifunctional tertiary amine building block used in pharmaceutical synthesis and specialty chemical manufacturing.

Its dual amine sites make it a reactive intermediate for constructing complex nitrogen-containing scaffolds in drug development pipelines. In pharmaceutical manufacturing, TAP serves as a key intermediate in synthesis.

This is particularly true where piperazine-based structural motifs are required in the final molecule. Biotechnology researchers use it in the preparation of linkers and conjugates for targeted drug delivery systems.

The compound also functions as a polymerization initiator or catalyst in specialty polymer formulations where controlled amine reactivity is required. In research-scale synthesis, it supports the development of libraries.

These heterocyclic compound libraries are used in high-throughput screening programs. 1-(2-Dimethylaminoethyl)piperazine is supplied as a liquid at standard commercial purities, typically ranging from 97% to 99%+.

Material is available in research quantities through to bulk industrial volumes to support both early-stage development and commercial manufacturing. Technical and high-purity grades are the most common.

These are the most commonly sourced specifications in pharmaceutical and biotechnology procurement. The product meets rigorous industrial requirements for consistency and performance in sensitive chemical reactions.

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Physical Properties

Boiling Point 94-95 °C @ Press: 8 Torr
Density 0.9165 g/cm³ @ Temp: 20 °C
Appearance Clear yellow liquid
Color Colourless
Form liquid
Refractive Index n 20/D 1.479

Safety & Handling (Learn More)

Danger GHS05
Hazard Statements
H314 Causes severe skin burns and eye damage
Precautionary Statements
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash … thoroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P316 Get emergency medical help immediately.
P321 Specific treatment (see … on this label).
P363 Wash contaminated clothing before reuse.
P405 Store locked up.
P501 Dispose of contents/container in accordance with local regulations.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P301+P330+P331 Rinse mouth. Do NOT induce vomiting.
P302+P361+P354 IF ON SKIN: Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P354+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code 29349990
UN Number 2735
ADR Class 8
Packing Group III
Storage Class 8A - Combustible corrosive hazardous materials
WGK (Germany) 3

Documentation

Other Names

Tap – 1-methyl-4-(2-dimethylaminoethyl)piperazine|N,n-dimethyl-2-piperazin-1-ylethanamine

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