Amines
REACH
Diethylpropargylamine
CAS Number
4079-68-9
EC Number
223-804-5
What is Diethylpropargylamine?
Diethylpropargylamine (CAS 4079-68-9), also known as 3-(Diethylamino)propyne, is a tertiary propargylic amine used as a reactive building block and polymerization initiator in specialty chemical synthesis.
Where is Diethylpropargylamine used?
- Pharmaceutical synthesis: intermediate for drug candidates, notably CNS and enzyme-inhibitor programs
- Medicinal chemistry: terminal alkyne supports copper-catalyzed azide-alkyne cycloaddition click chemistry for conjugation steps
- Polymer science: initiator or co-monomer for stimuli-responsive or functionalized polymers requiring pendant amine and alkyne groups
- Biotechnology: clickable handles on biomolecules for labeling, immobilization or probe development
- Its terminal alkyne group serves as a handle for constructing complex molecular architectures.
Commercial specifications
- Research and development scales
- High-purity grades for pharmaceutical intermediate and life sciences applications
Other Names (Synonyms)
2-Propyn-1-amine, N,N-diethyl-|N,N-Diethyl-2-propynylamine|3-(Diethylamino)propyne|3-(N,N-Diethylamino)propyne|1-N,N-Diethylamino-2-propyne|2-PROPYNYLAMINE, N,N-DIETHYL-|N,N-Diethyl-2-propyn-1-amine|N,N-Diethylpropargylamine
What are the physical properties of Diethylpropargylamine?
Melting Point 157-161°C
Boiling Point 120-121 °C
Density 0.8042 g/cm³ @ Temp: 25 °C
Flash Point 156°C
Color Colorless to Light orange to Yellow
Form clear liquid
Water Solubility Soluble in acid. Insoluble in water.
Vapor Pressure 14.6hPa at 20℃
Refractive Index n 20/D 1.434
Log P 1.5 at 23℃
How is Diethylpropargylamine classified and handled safely? Learn More
Danger
GHS02· Flammable GHS05· Corrosive GHS06· Toxic GHS07· Irritant
Hazard Statements
H225 Highly Flammable liquid and vapor
H226 Flammable liquid and vapor
H302 Harmful if swallowed
H311 Toxic in contact with skin
Precautionary Statements
P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
P233 Keep container tightly closed.
P240 Ground and bond container and receiving equipment.
P241 Use explosion-proof [electrical/ventilating/lighting/…] equipment.
Which trade and regulatory codes apply to Diethylpropargylamine?
HS Code 29211990
UN Number 2733
ADR Class 3
Packing Group II
WGK (Germany) 3