Amines
REACH
Piperazine
CAS Number
110-85-0
EC Number
203-808-3
FEMA Number
FEMA 4250
What is Piperazine?
Piperazine (CAS 110-85-0), also known commercially as Vermizine, is a cyclic diamine used as a reactive building block and process chemical in pharmaceutical manufacturing and polymer production.
Where is Piperazine used?
- Pharmaceutical manufacturing: key structural unit in the synthesis of drug compounds, including antipsychotics, antihistamines and antiparasitic agents
- Polymer production: curing agent and cross-linker in epoxy resin systems, where controlled amine reactivity determines final mechanical performance
- Polyamide membranes: monomer for membranes used in water treatment and industrial filtration
- Agrochemical synthesis: core intermediate in fungicide and pesticide formulations
- Its bifunctional amine structure makes it an intermediate for synthesizing active pharmaceutical ingredients and specialty materials.
Commercial specifications
- Pharmaceutical-grade material meets USP and BP specifications
- Bulk quantities typically offered in multi-kilogram bags and drums
Other Names (Synonyms)
Vermizine (tn)|Piperazin|1,4-Diazinane|1,4-Diazacyclohexane|Antiren
What are the physical properties of Piperazine?
Melting Point 106 °C
Boiling Point 146 °C @ Press: 760 Torr
Density 1.1 g/cm³
Flash Point 65 °C
Appearance Solid
Color White to slightly yellow
Odor at 0.10 % in dipropylene glycol. ammoniacal
Form Crystalline Flakes
Water Solubility 150 g/L (20 ºC)
Vapor Pressure 0.8 mm Hg ( 20 °C)
Refractive Index 1.4460
pH 11.0-12.5 (25℃, 0.1M in H2O)
Log P -1.24 at 20-25℃
How is Piperazine classified and handled safely? Learn More
Danger
GHS05· Corrosive GHS08· Health Hazard GHS02· Flammable GHS07· Irritant
Hazard Statements
H228 Flammable solid
H302 Harmful if swallowed
H312 Harmful in contact with skin
H314 Causes severe skin burns and eye damage
Precautionary Statements
P203 Obtain, consult and follow expert instructions for use.
P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
P233 Keep container tightly closed.
P240 Ground and bond container and receiving equipment.
Which trade and regulatory codes apply to Piperazine?
HS Code 29335900
UN Number 2579
ADR Class 8
Packing Group III
Storage Class 4.1B - Flammable solid hazardous materials
WGK (Germany) 1