1-methylimidazole

CAS Number
616-47-7
EC Number
210-484-7
Abbreviation
NMI

What is 1-methylimidazole?

1-Methylimidazole (CAS 616-47-7), commonly abbreviated as NMI, is a nitrogen-containing heterocyclic compound used industrially as a catalyst, curing agent, and synthesis intermediate.

Where is 1-methylimidazole used?

  • Pharmaceutical manufacturing: coupling catalyst in peptide synthesis and acylation reactions
  • Polymer chemistry and specialty coatings: building block due to reactivity toward electrophiles and metal coordination
  • Epoxy resin systems: latent curing agent and cure accelerator for controlled crosslinking in electrical laminates, adhesives, and industrial coatings
  • Ionic liquids: precursor for imidazolium-based salts used as reaction media or electrolytes in battery and electrochemical applications
  • Organometallic processes: ligand or co-catalyst supporting API production and fine chemical synthesis

Good to know: Buyers should confirm water content and color specifications when sourcing for sensitive catalytic applications.

Commercial specifications

  • High-purity grades are available for pharmaceutical and electronic applications.

Other Names (Synonyms)

N-Methylimidazole|1-Methyl-1H-imidazole|1H-Imidazole, 1-methyl-|IMIDAZOLE, 1-METHYL-|P4617QS63Y|1-methyl-1H-imidazol-3-ium|N1-Methylimidazole|NMI

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What are the physical properties of 1-methylimidazole?

Melting Point -6 °C
Boiling Point 198-199 °C
Density 1.035 g/cm³ (liquid)
Flash Point 198 °F
Appearance Clear colorless to yellow liquid
Color Clear colorless to yellow
Form Liquid
Water Solubility Miscible with water.
Vapor Pressure 0.4 mm Hg ( 20 °C)
Refractive Index n 20/D 1.495(lit.)
pH 9.5-10.5 (50g/l, H2O, 20℃)
Log P -0.19 at 25℃

How is 1-methylimidazole classified and handled safely? Learn More

Danger
GHS05· Corrosive GHS07· Irritant GHS06· Toxic GHS08· Health Hazard

Hazard Statements

H302 Harmful if swallowed
H311 Toxic in contact with skin
H312 Harmful in contact with skin
H314 Causes severe skin burns and eye damage
H318 Causes serious eye damage

Precautionary Statements

P203 Obtain, consult and follow expert instructions for use.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P262 Do not get in eyes, on skin, or on clothing.
P264 Wash … thoroughly after handling.

Which trade and regulatory codes apply to 1-methylimidazole?

HS Code 29332990
UN Number 3267
ADR Class 8
Packing Group II
WGK (Germany) 1
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