N-methylmorpholine

N-methylmorpholine (CAS 109-02-4), commonly abbreviated as NMM, is a tertiary amine solvent and catalyst.

Where is N-methylmorpholine used?

• Pharmaceutical manufacturing: non-nucleophilic base in peptide coupling reactions for cleaner synthesis of active pharmaceutical ingredients
• Polyurethane foam and elastomer production: catalyst controlling gel and blow reaction timing, affecting density and mechanical performance
• Coatings and adhesives: promotes crosslinking and improves adhesion to difficult substrates
• Printing inks: co-solvent improving pigment dispersion and resin compatibility
• It also serves as a base catalyst and reaction solvent where controlled basicity and miscibility with water and organic media are required.

Good to know: Technical grade is the most common commercial specification; high-purity grades meet pharmaceutical manufacturing requirements.

Commercial specifications

• Bulk quantities including drums and IBC containers
• Smaller packaging for laboratory and specialty use