Amines REACH

Morpholine

CAS Number
110-91-8
EC Number
203-815-1
Chemical Formula
C4H9NO
Molecular Weight
87.12 g/mol

Description

Morpholine (CAS 110-91-8) is a cyclic amine and ether used across industrial chemistry as a corrosion inhibitor, chemical intermediate, and curing agent. Its dual amine-ether functionality makes it a building block for a broad range of downstream synthesis applications. In steam boiler and water treatment systems, morpholine is dosed to neutralize carbonic acid and suppress corrosion in condensate return lines. It serves as a well-established alternative to volatile amines in these environments.

Pharmaceutical manufacturers use it as a synthetic intermediate in the production of active ingredients, where its secondary amine group enables targeted derivatization. This versatility is critical for complex chemical synthesis. In rubber and polymer processing, morpholine-based accelerators and crosslinkers improve cure rates and mechanical performance in finished elastomer products. These additives are essential for high-performance industrial rubber goods.

Metalworking fluid formulators incorporate morpholine as a pH buffer and biocide component to extend fluid service life. This helps control microbial growth in demanding cutting and grinding operations across the manufacturing sector. Morpholine is supplied as a clear liquid in standard drum, IBC, and bulk tanker quantities. Technical grade is the primary commercial form, with high-purity grades available for specialized pharmaceutical synthesis applications.

Buyers should confirm purity specifications and water content when sourcing for API intermediate use. Ensuring the material meets specific industrial requirements is vital for maintaining process stability and final product quality.

Other Names (Synonyms)

tetrahydro-p-oxazine|tetrahydro-1,4-oxazine|diethylene oximide|diethylene imidoxide|1-Oxa-4-azacyclohexane|Diethylenimide oxide|Diethyleneimide oxide|Drewamine

Key Technical Features

  • High Purity Grade standard
  • Consistent Batch Quality
  • Full Regulatory & REACH Support
  • Global Logistics Network enabled

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Physical Properties

Melting Point -4.9 °C
Boiling Point 128.9 °C @ Press: 760 Torr
Density 1.0007 g/cm³ @ Temp: 20 °C
Flash Point 96 °F
Appearance Morpholine is a colorless liquid with a weak ammonia or fish-like odor. The odor threshold is 0.01 ppm.
Color APHA: ≤15
Odor Characteristic amine-like odor
Form Liquid
Water Solubility MISCIBLE
Vapor Pressure 31 mm Hg ( 38 °C)
Refractive Index n 20/D 1.454(lit.)
pH 11.2 (H2O)(undiluted)
Log P -0.860

Documentation

Safety & Handling Learn More

Danger
GHS02· Flammable GHS05· Corrosive GHS07· Irritant GHS09· Environmental Hazard GHS06· Toxic GHS08· Health Hazard

Hazard Statements

H226 Flammable liquid and vapor
H290 May be corrosive to metals
H302 Harmful if swallowed
H311 Toxic in contact with skin

Precautionary Statements

P203 Obtain, consult and follow expert instructions for use.
P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
P233 Keep container tightly closed.
P234 Keep only in original packaging.

Trade & Regulatory

HS Code 29349900
UN Number 2054
ADR Class 8
Packing Group I
Storage Class 3 - Flammable liquids
WGK (Germany) 3
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