Amines
REACH
Morpholine
CAS Number
110-91-8
EC Number
203-815-1
What is Morpholine?
Morpholine (CAS 110-91-8) is a cyclic amine and ether used in industrial chemistry as a corrosion inhibitor, chemical intermediate, and curing agent.
Where is Morpholine used?
- Water treatment: dosed in steam boiler systems to neutralize carbonic acid and suppress corrosion in condensate return lines
- Pharmaceuticals: synthetic intermediate in the production of active ingredients, its secondary amine group enabling targeted derivatization
- Rubber and polymer processing: morpholine-based accelerators and crosslinkers improve cure rates and mechanical performance in elastomer products
- Metalworking fluids: pH buffer and biocide component that extends fluid service life
- Its dual amine-ether functionality makes it a building block for downstream synthesis.
Good to know: Buyers should confirm purity specifications and water content when sourcing for API intermediate use.
Commercial specifications
- Standard drum, IBC, and bulk tanker quantities
- Technical grade is the primary commercial form; high-purity grades for pharmaceutical synthesis
Other Names (Synonyms)
tetrahydro-p-oxazine|tetrahydro-1,4-oxazine|diethylene oximide|diethylene imidoxide|1-Oxa-4-azacyclohexane|Diethylenimide oxide|Diethyleneimide oxide|Drewamine
What are the physical properties of Morpholine?
Melting Point -4.9 °C
Boiling Point 128.9 °C @ Press: 760 Torr
Density 1.0007 g/cm³ @ Temp: 20 °C
Flash Point 96 °F
Appearance Morpholine is a colorless liquid with a weak ammonia or fish-like odor. The odor threshold is 0.01 ppm.
Color APHA: ≤15
Odor Characteristic amine-like odor
Form Liquid
Water Solubility MISCIBLE
Vapor Pressure 31 mm Hg ( 38 °C)
Refractive Index n 20/D 1.454(lit.)
pH 11.2 (H2O)(undiluted)
Log P -0.860
How is Morpholine classified and handled safely? Learn More
Danger
GHS02· Flammable GHS05· Corrosive GHS07· Irritant GHS09· Environmental Hazard GHS06· Toxic GHS08· Health Hazard
Hazard Statements
H226 Flammable liquid and vapor
H290 May be corrosive to metals
H302 Harmful if swallowed
H311 Toxic in contact with skin
Precautionary Statements
P203 Obtain, consult and follow expert instructions for use.
P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
P233 Keep container tightly closed.
P234 Keep only in original packaging.
Which trade and regulatory codes apply to Morpholine?
HS Code 29349900
UN Number 2054
ADR Class 8
Packing Group I
Storage Class 3 - Flammable liquids
WGK (Germany) 3