6-hydroxybenzomorpholine
Description
6-Hydroxybenzomorpholine (CAS 26021-57-8), also referenced as 3,4-Dihydro-2H-1,4-benzoxazin-6-ol, is a hydroxyl-functionalized benzoxazine heterocycle used as a building block.
It is utilized in pharmaceutical synthesis and specialty chemical manufacturing. Its reactive phenolic hydroxyl group makes it a sought-after intermediate for constructing complex molecular architectures.
In pharmaceutical synthesis, this compound serves as a key intermediate for active pharmaceutical ingredient development. Its benzoxazine scaffold supports the construction of targeted small-molecule candidates.
The compound's hydroxyl functionality enables conjugation and derivatization steps critical to medicinal chemistry workflows. It is essential for researchers working on drug development pipelines.
In polymer chemistry, it functions as a polymerization initiator, particularly in ring-opening systems where controlled initiation is required. This allows for precise chemical engineering.
Biotechnology researchers also employ it in the preparation of probe molecules and ligand scaffolds for receptor binding studies. This versatility makes it a valuable asset in various labs.
The material is supplied as a solid powder, typically at high purity levels suited to research and intermediate-scale synthesis. It is available in research quantities through to kilogram lots.
Specifications are generally aligned with pharmaceutical intermediate standards. Documentation provided includes a COA, HPLC purity data, and NMR confirmation to ensure chemical integrity.
Physical Properties
| Boiling Point | 334.7±42.0 °C(Predicted) |
| Density | 1.241±0.06 g/cm3(Predicted) |
| Color | Black |
| Form | Solid |
| Water Solubility | 19g/L@20°C |
| Vapor Pressure | 0.002Pa@20°C |
| Log P | 0.219 at 23℃ |
Safety & Handling (Learn More)
Trade & Regulatory
| HS Code | 2934999090 |
Documentation
Other Names
3,4-Dihydro-2H-1,4-benzoxazin-6-ol|2H-1,4-Benzoxazin-6-ol, 3,4-dihydro-|77OXT3492A|3,4-DIHYDRO-2H-BENZO-(B)(1,4)OXAZIN-6-OL|3,4-DIHYDRO-6-HYDROXY-1,4(2H)-BENZOXAZINE|6-Hydroxyphenomorpholine
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