SoleChem

6-hydroxybenzomorpholine

CAS
26021-57-8
EC
247-415-5
Mol. Weight
151.16 g/mol

Description

6-Hydroxybenzomorpholine (CAS 26021-57-8), also referenced as 3,4-Dihydro-2H-1,4-benzoxazin-6-ol, is a hydroxyl-functionalized benzoxazine heterocycle used as a building block.

It is utilized in pharmaceutical synthesis and specialty chemical manufacturing. Its reactive phenolic hydroxyl group makes it a sought-after intermediate for constructing complex molecular architectures.

In pharmaceutical synthesis, this compound serves as a key intermediate for active pharmaceutical ingredient development. Its benzoxazine scaffold supports the construction of targeted small-molecule candidates.

The compound's hydroxyl functionality enables conjugation and derivatization steps critical to medicinal chemistry workflows. It is essential for researchers working on drug development pipelines.

In polymer chemistry, it functions as a polymerization initiator, particularly in ring-opening systems where controlled initiation is required. This allows for precise chemical engineering.

Biotechnology researchers also employ it in the preparation of probe molecules and ligand scaffolds for receptor binding studies. This versatility makes it a valuable asset in various labs.

The material is supplied as a solid powder, typically at high purity levels suited to research and intermediate-scale synthesis. It is available in research quantities through to kilogram lots.

Specifications are generally aligned with pharmaceutical intermediate standards. Documentation provided includes a COA, HPLC purity data, and NMR confirmation to ensure chemical integrity.

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Physical Properties

Boiling Point 334.7±42.0 °C(Predicted)
Density 1.241±0.06 g/cm3(Predicted)
Color Black
Form Solid
Water Solubility 19g/L@20°C
Vapor Pressure 0.002Pa@20°C
Log P 0.219 at 23℃

Safety & Handling (Learn More)

Warning GHS07 GHS09
Hazard Statements
H302 Harmful if swallowed
H319 Causes serious eye irritation
H411 Toxic to aquatic life with long lasting effects
Precautionary Statements
P264 Wash … thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P330 Rinse mouth.
P391 Collect spillage.
P501 Dispose of contents/container in accordance with local regulations.
P264+P265 Wash … thoroughly after handling.
P301+P317 Get emergency medical help.
P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code 2934999090

Documentation

Other Names

3,4-Dihydro-2H-1,4-benzoxazin-6-ol|2H-1,4-Benzoxazin-6-ol, 3,4-dihydro-|77OXT3492A|3,4-DIHYDRO-2H-BENZO-(B)(1,4)OXAZIN-6-OL|3,4-DIHYDRO-6-HYDROXY-1,4(2H)-BENZOXAZINE|6-Hydroxyphenomorpholine

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