3-Bromoquinoline
Description
3-Bromoquinoline (CAS 5332-24-1) is a halogenated heterocyclic building block used primarily in pharmaceutical synthesis and specialty chemical manufacturing. The bromine substituent at the 3-position makes it a reactive intermediate for cross-coupling reactions.
This functionality enables the efficient construction of more complex quinoline-based structures. In pharmaceutical development, it serves as a key intermediate for synthesizing active pharmaceutical ingredients and drug candidates.
This is particularly relevant where quinoline scaffolds are required for biological activity. Polymer and plastics manufacturers incorporate brominated quinoline derivatives into flame retardant formulations for industrial use.
In these applications, the halogen content contributes to combustion suppression in finished materials. In textile and paper treatment chemistries, it functions as a precursor to preservation and stabilization compounds.
These compounds protect substrates from degradation over time. Research and fine chemical producers also source it for producing ligands, dyes, and specialty reagents where a functionalized quinoline core is the starting point.
3-Bromoquinoline is supplied as a liquid or low-melting solid, typically at purities of 97% or higher for synthetic and research applications. Technical and high-purity grades are available to meet specific requirements.
These grades support pharmaceutical intermediates manufacturing and specialty chemical production. Packaging ranges from small quantities for R&D use to bulk quantities for industrial-scale synthesis programs.
Physical Properties
| Melting Point | 13.3 °C |
| Boiling Point | 103-105 °C @ Press: 1.5 Torr |
| Density | 1.533 g/mL at 25 °C(lit.) |
| Flash Point | >230 °F |
| Appearance | colorless to light yellow liquid |
| Color | Clear colorless to yellow |
| Form | Liquid |
| Water Solubility | 103mg/L at 25℃ |
| Vapor Pressure | 0.196Pa at 25℃ |
| Refractive Index | n 20/D 1.664(lit.) |
| Log P | 3.03 |
Safety & Handling (Learn More)
Trade & Regulatory
| HS Code | 29334900 |
| UN Number | 2810 |
| Storage Class | 10 - Combustible liquids |
| WGK (Germany) | 3 |
Documentation
Other Names
Quinoline, 3-bromo-|AI3-16560|RefChem:93267|Quinolin-3-yl bromide|DI-SEC-BUTYLAMINE
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