Chloroquine

CAS Number
54-05-7
EC Number
200-191-2

What is Chloroquine?

Chloroquine (CAS 54-05-7) is a synthetic 4-aminoquinoline compound used as a pharmaceutical active ingredient and research chemical.

Where is Chloroquine used?

  • Drug development: primary building block and analytical reference standard
  • Pharmaceutical manufacturing: active ingredient in tablets and oral solutions for parasitic indications
  • Analytical method validation: reference standard for research institutions and contract development organizations
  • Bioequivalence studies and pharmacokinetic assays
  • Drug discovery: scaffold compound for synthesizing novel quinoline-based derivatives
  • Generic drug development: comparator substance for formulation optimization and stability testing
  • Research-grade material is supplied for non-GMP laboratory applications and experimental chemical synthesis.

Good to know: Available as a free base or, more commonly, as Chloroquine phosphate, the predominant commercial salt form. Standard grades include USP, BP, and Ph. Eur. specifications.

Commercial specifications

  • Base or phosphate salt form
  • Standard grades: USP, BP, Ph. Eur.
  • Packaging from small reference quantities to bulk commercial API manufacturing

Other Names (Synonyms)

N4-(7-chloro-4-quinolinyl)-N1,N1-diethyl-1,4-pentanediamine|7-chloro-4-{[4-(diethylamino)-1-methylbutyl]amino}quinolinium|(RS)-chloroquine|Aralen|Artrichin|Bipiquin|1,4-Pentanediamine, N4-(7-chloro-4-quinolinyl)-N1,N1-diethyl-|Quinoline, 7-chloro-4-[[4-(diethylamino)-1-methylbutyl]amino]-

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What are the physical properties of Chloroquine?

Melting Point 87-92 °C
Boiling Point 230-235 °C @ Press: 3-4 Torr
Density 1.0500 (rough estimate)
Appearance solid
Color White to Light Brown
Form Solid
Refractive Index 1.6010 (estimate)

How is Chloroquine classified and handled safely? Learn More

Warning
GHS07· Irritant

Hazard Statements

H302 Harmful if swallowed

Precautionary Statements

P264 Wash … thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P330 Rinse mouth.
P501 Dispose of contents/container in accordance with local regulations.
P301+P317 Get emergency medical help.
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