Amines REACH

Chlorhexidine dihydrochloride

CAS Number
3697-42-5
EC Number
223-026-6
Chemical Formula
C22H30Cl2N10.2ClH
Molecular Weight
578.4 g/mol

Description

Chlorhexidine dihydrochloride (CAS 3697-42-5), also known as chlorhexidine hydrochloride, is a broad-spectrum antimicrobial active used across pharmaceutical, personal care, and industrial applications. It delivers effective bactericidal and fungicidal action against a wide range of gram-positive and gram-negative organisms. Procurement teams source it as a primary biocidal ingredient where water-soluble salt forms are required.

In pharmaceutical manufacturing, it is formulated into antiseptic wound washes, surgical scrubs, and mucous membrane disinfectants. A water-soluble salt form is often preferred over the diacetate or digluconate versions. Personal care producers incorporate it into antibacterial hand washes, medicated shampoos, and oral rinse concentrates targeting microbial control. It functions as a preservative active in various topical formulations.

Industrial water treatment operations use it as a biocide to control microbial growth in cooling systems and process water. It is highly effective where regulatory specifications call for a defined chlorhexidine salt. Chlorhexidine dihydrochloride is supplied as a white to off-white crystalline powder. Standard grades include pharmaceutical-grade material conforming to BP and Ph. Eur. specifications for global compliance.

Technical grade is also available for industrial and water treatment end uses. Packaging is typically offered in kilogram quantities up to bulk drum supply to suit both formulation-scale and large-volume procurement needs.

Other Names (Synonyms)

(1E)-2-[6-[[amino-[(E)-[amino-(4-chloroanilino)methylidene]amino]methylidene]amino]hexyl]-1-[amino-(4-chloroanilino)methylidene]guanidine;dihydrochloride|Chlorhexidine hydrochloride

Key Technical Features

  • High Purity Grade standard
  • Consistent Batch Quality
  • Full Regulatory & REACH Support
  • Global Logistics Network enabled

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Physical Properties

Melting Point 256 °C
Density 1.284[at 20℃]
Appearance White Crystalline Solid
Color White to Off-White
Odor odorless
Form neat
Water Solubility 0.06 g/100 mL (20 ºC)
Vapor Pressure 0.003Pa at 25℃
Log P -1.94 at 22.2℃

Safety & Handling (Learn More)

Warning
GHS07· Irritant GHS08· Health Hazard GHS09· Environmental Hazard GHS05· Corrosive

Hazard Statements

H317 May cause an allergic skin reaction [Warning Sensitization, Skin]
H318 Causes serious eye damage [Danger Serious eye damage/eye irritation]
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]

Trade & Regulatory

HS Code 29252900
UN Number 2811
ADR Class 6.1
Packing Group I
Storage Class 11 - Combustible Solids
WGK (Germany) 3

Documentation

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