Chlorhexidine dihydrochloride

CAS Number
3697-42-5
EC Number
223-026-6

What is Chlorhexidine dihydrochloride?

Chlorhexidine dihydrochloride (CAS 3697-42-5), also known as chlorhexidine hydrochloride, is a broad-spectrum antimicrobial active.

Where is Chlorhexidine dihydrochloride used?

  • Pharmaceutical manufacturing: antiseptic wound washes, surgical scrubs, mucous membrane disinfectants
  • Personal care: antibacterial hand washes, medicated shampoos, oral rinse concentrates
  • Preservative active in topical formulations
  • Industrial water treatment: biocide controlling microbial growth in cooling systems and process water
  • It delivers bactericidal and fungicidal action against gram-positive and gram-negative organisms.

Good to know: A water-soluble salt form, often preferred over the diacetate or digluconate versions. Standard grades include pharmaceutical-grade material conforming to BP and Ph. Eur. specifications; technical grade is also available for industrial and water treatment end uses.

Commercial specifications

  • Packaging in kilogram quantities up to bulk drum supply

Other Names (Synonyms)

(1E)-2-[6-[[amino-[(E)-[amino-(4-chloroanilino)methylidene]amino]methylidene]amino]hexyl]-1-[amino-(4-chloroanilino)methylidene]guanidine;dihydrochloride|Chlorhexidine hydrochloride

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What are the physical properties of Chlorhexidine dihydrochloride?

Melting Point 256 °C
Density 1.284[at 20℃]
Appearance White Crystalline Solid
Color White to Off-White
Odor odorless
Form neat
Water Solubility 0.06 g/100 mL (20 ºC)
Vapor Pressure 0.003Pa at 25℃
Log P -1.94 at 22.2℃

How is Chlorhexidine dihydrochloride classified and handled safely? Learn More

Warning
GHS07· Irritant GHS08· Health Hazard GHS09· Environmental Hazard GHS05· Corrosive

Hazard Statements

H317 May cause an allergic skin reaction [Warning Sensitization, Skin]
H318 Causes serious eye damage [Danger Serious eye damage/eye irritation]
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]

Which trade and regulatory codes apply to Chlorhexidine dihydrochloride?

HS Code 29252900
UN Number 2811
ADR Class 6.1
Packing Group I
Storage Class 11 - Combustible Solids
WGK (Germany) 3
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