Quinine hydrochloride dihydrate

CAS Number
6119-47-7
EC Number
205-001-1
FEMA Number
FEMA 2976

What is Quinine hydrochloride dihydrate?

Quinine hydrochloride dihydrate (CAS 6119-47-7), referenced as Quinine HCl Dihydrate in pharmaceutical procurement, is the water-soluble hydrochloride salt form of quinine in its stable dihydrate state.

Where is Quinine hydrochloride dihydrate used?

  • Pharmaceutical manufacturing: active pharmaceutical ingredient in antimalarial formulations
  • Beverage and flavoring: intensely bitter profile to standardize bitterness
  • Tonic formulations and reference standards
  • Personal care and cosmetics: scalp treatments and hair care products targeting hair loss and scalp conditioning
  • QA and analytical laboratories use it as a reference standard for UV fluorescence calibration and spectrophotometric method validation.

Good to know: Its hydrochloride salt form offers improved aqueous solubility over quinine sulfate for injectable and oral dosage development.

Commercial specifications

  • Pharmaceutical-grade specifications aligned with BP and Ph. Eur. monographs
  • Supports GMP-compliant manufacturing environments
  • Packaging ranges from small to bulk quantities

Other Names (Synonyms)

Quinine HCl Dihydrate|Cinchonan-9-ol, 6'-methoxy-, monohydrochloride, dihydrate, (8a,9R)-|Quinidine Hydrochloride Dihydrate|Cinchonan-9-ol, 6′-methoxy-, hydrochloride, hydrate (1:1:2), (8α,9R)-|Cinchonan-9-ol, 6′-methoxy-, monohydrochloride, dihydrate, (8α,9R)-

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What are the physical properties of Quinine hydrochloride dihydrate?

Melting Point 123 °C (approx)
Flash Point 122 °C
Appearance white to light yellow crystal powde
Color White to off-white
Odor odorless
Form Crystalline Powder or Silky Needles
Water Solubility Sparingly soluble in water.(0.26 g/L) (25°C),
Refractive Index -250 ° (C=2, EtOH)
pH 6.0 (10g/l, H2O, 20℃)

How is Quinine hydrochloride dihydrate classified and handled safely? Learn More

Warning
GHS07· Irritant GHS08· Health Hazard

Hazard Statements

H302 H302
H317 H317
H332 H332
H334 H334

Precautionary Statements

P233 P233
P260 P260
P261 P261
P264 P264

Which trade and regulatory codes apply to Quinine hydrochloride dihydrate?

HS Code 29334900
Storage Class 11 - Combustible Solids
WGK (Germany) 3
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