Lisinopril dihydrate

CAS Number
83915-83-7
EC Number
627-033-9

What is Lisinopril dihydrate?

Lisinopril dihydrate (CAS 83915-83-7) is the stable, hydrated crystalline form of lisinopril, a lysine-proline derivative used as an active pharmaceutical ingredient in antihypertensive drug manufacturing.

Where is Lisinopril dihydrate used?

  • Oral solid dosage forms: API in tablets and capsules for hypertension and heart failure
  • Combination antihypertensive products: with diuretics such as hydrochlorothiazide in fixed-dose tablets
  • Contract manufacturing and generic production: pharmaceutical intermediate for direct compression or wet granulation
  • QA laboratories and analytical teams procure reference standard quantities for method validation and release testing.

Good to know: The dihydrate form is the commercially preferred specification for finished dosage form production, offering consistent physical stability under standard storage conditions.

Commercial specifications

  • Pharmaceutical-grade specifications meeting USP, BP, and Ph. Eur. compendial standards
  • Packaging from small laboratory quantities to bulk commercial manufacturing quantities

Other Names (Synonyms)

LISINOPRIL DIHYDRATE [MI]|LISINOPRIL DIHYDRATE [WHO-DD]|N(2)-[(1S)-1-carboxy-3-phenylpropyl]-L-lysyl-L-proline dihydrate|(S)-1-(N(2)-(1-carboxy-3-phenylpropyl)-L-lysyl)-L-proline dihydrate|RefChem:799369|L-Proline, N2-[(1S)-1-carboxy-3-phenylpropyl]-L-lysyl-, hydrate (1:2)|L-Proline, 1-[N2-(1-carboxy-3-phenylpropyl)-L-lysyl]-, dihydrate, (S)-

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What are the physical properties of Lisinopril dihydrate?

Melting Point 148 °C
Appearance White to Off-White Crystalline Powder
Color white
Form solid
Water Solubility H2O: ≥10mg/mL DMSO: ~6.5mg/mL (with heating and sonicating)
Refractive Index -45 ° (C=1, 0.25mol/L Zinc Acetate Buffer)

How is Lisinopril dihydrate classified and handled safely? Learn More

Danger
GHS08· Health Hazard

Hazard Statements

H360 May damage fertility or the unborn child
H361 Suspected of damaging fertility or the unborn child
H373 May causes damage to organs through prolonged or repeated exposure

Precautionary Statements

P203 Obtain, consult and follow expert instructions for use.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P318 IF exposed or concerned, get medical advice.

Which trade and regulatory codes apply to Lisinopril dihydrate?

HS Code 2933995300
Storage Class 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects
WGK (Germany) 3
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