Sitagliptin phosphate

Sitagliptin phosphate (CAS 654671-78-0) is the phosphate salt form of sitagliptin, a DPP-4 inhibitor active pharmaceutical ingredient for managing type 2 diabetes.

Where is Sitagliptin phosphate used?

• Oral antidiabetic tablet formulations: active ingredient
• DPP-4 enzyme inhibitor delivering the therapeutic effect
• Fixed-dose combination tablets paired with metformin, requiring compatibility evaluation
• Reference-grade material for method validation in analytical and QA laboratories
• Pharmaceutical manufacturers and API importers source both hydrate forms as the basis for finished oral dosage production.

Good to know: Sitagliptin phosphate monohydrate is the primary commercially distributed hydrate form; the anhydrous grade serves distinct formulation requirements. Specifications are aligned to pharmacopoeial standards such as USP, Ph. Eur., BP, and EP.

Commercial specifications

• API-grade material manufactured under ICH Q7 GMP guidelines
• Packaging typically in kilogram-scale quantities suited to clinical batch manufacturing and commercial production runs