Sildenafil citrate

Sildenafil citrate (CAS 171599-83-0), also marketed as Viagra and Revatio, is a phosphodiesterase type 5 (PDE5) inhibitor used as an active pharmaceutical ingredient in prescription drug manufacturing.

Where is Sildenafil citrate used?

• Pharmaceutical manufacturing: controlled API for finished dosage form production
• Oral solid dosage forms: tablets and film-coated tablets for erectile dysfunction, active ingredient at defined therapeutic concentrations
• Revatio-branded formulations target pulmonary arterial hypertension, a distinct regulatory and manufacturing pathway requiring separate specifications
• Generic drug manufacturing: bulk API for bioequivalent products measured against reference listed drugs
• Contract manufacturers use it in suspension formulations for pediatric pulmonary hypertension indications.

Good to know: Revatio-branded formulations represent a distinct regulatory and manufacturing pathway requiring separate product specifications. Sourcing typically requires compliance documentation including CoA, DMF references, and GMP certification from the manufacturing site.

Commercial specifications

• Bulk quantities suited to pharmaceutical-scale production
• CoA, DMF references, GMP certification