Bismuth citrate
Description
Bismuth citrate (CAS 813-93-4) is an inorganic bismuth salt used primarily as a pharmaceutical intermediate and active ingredient precursor in gastrointestinal and antimicrobial drug formulations.
It functions as a stabilizing agent and buffering component in formulations where controlled bismuth delivery is required. In pharmaceutical manufacturing, it serves as a key starting material for synthesis.
This material is essential for synthesizing colloidal bismuth subcitrate and related compounds used in peptic ulcer and H. pylori treatment protocols. Topical and dermatological formulations incorporate it as a mild preservative.
It acts as a stabilizer particularly where metal-based biocidal activity is needed at low concentrations. In cosmetic manufacturing, it supports pH regulation and acts as a stabilizing agent in creams and ointments.
Food-contact and nutritional supplement applications represent a smaller but established market. In these sectors, it is evaluated as a mineral source under controlled regulatory frameworks for specific consumer products.
Bismuth citrate is supplied as a white to off-white powder. Standard grades include pharmaceutical-grade material meeting USP and BP specifications, with technical-grade material available for industrial use.
Purity specifications typically range from 98% upward. Documentation packages including COA and heavy metals testing are commonly expected by pharmaceutical buyers to ensure compliance with global safety standards.
Physical Properties
| Melting Point | 300 °C (dec.) (lit.) |
| Density | 0.94 g/mL at 25 °C(lit.) |
| Appearance | White Crystalline Powder |
| Color | White |
| Form | Crystalline Powder |
| Water Solubility | Insoluble in water, alcohol, ether. Soluble in ammonia solution and in solution of alkali citrates. Typical tap density 0.50g/cm^3.Soluble in ammonia, alkali citrates. Insoluble in water, alcohol and ether. |
| Vapor Pressure | 0Pa at 20℃ |
| Log P | -0.37 at 25℃ |
Trade & Regulatory
| HS Code | 2918150000 |
| Storage Class | 11 - Combustible Solids |
| WGK (Germany) | 3 |
Documentation
Other Names
Bi-citrate|1,2,3-Propanetricarboxylic acid, 2-hydroxy-, bismuth(3+) salt (1:1)|N04867Y76N|RefChem:569474|Bismuth(III) citrate|Bismuth, [citrato(3-)]-|Tegokat 752
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