Valsartan
CAS Number
137862-53-4
EC Number
604-045-2
Industries: Pharma & Healthcare
What is Valsartan?
Valsartan (CAS 137862-53-4), also known as VAL489, is an angiotensin II receptor antagonist used as an active pharmaceutical ingredient in the treatment of hypertension and heart failure.
Where is Valsartan used?
- Cardiovascular drug formulations: core API
- Oral solid dosage forms such as tablets and capsules for antihypertensive therapy: primary active ingredient
- Combination products with hydrochlorothiazide or amlodipine
- Generic drug production: key API for formulation development and bioequivalence testing
- Regulatory filing and clinical trials
- Analytical reference standards and method development work by contract research organizations and formulation labs
- It is evaluated within peptide-adjacent research programs targeting cardiovascular peptide pathways.
Good to know: It functions by selectively blocking the AT1 receptor subtype. Pharmaceutical-grade specifications conform to USP, Ph. Eur. (EP), and BP monographs, supporting GMP-compliant manufacturing.
Commercial specifications
- Pharmaceutical-grade specifications conforming to USP, Ph. Eur. (EP), and BP monographs
- Quantities from research-scale lots to multi-kilogram commercial batches
- Documentation packages including CoA, DMF references, and impurity profiles available on request
Other Names (Synonyms)
VAL489|N-pentanoyl-N-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-L-valine|N-(p-(o-1H-tetrazol-5-ylphenyl)benzyl)-N-valeryl-L-valine|(S)-N-valeryl-N-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]-methyl}-valine|Diovan|80M03YXJ7I
What are the physical properties of Valsartan?
Melting Point 116-117 °C
Boiling Point 684.9±65.0 °C(Predicted)
Density 1.286 g/cm³
Appearance White Crystalline Powder
Color white to tan
Form powder
Water Solubility 84.99mg/L(25 ºC)
Vapor Pressure 0-0Pa at 20-25℃
Log P 1.2-2.8 at 25℃ and pH2.5-7
How is Valsartan classified and handled safely? Learn More
Warning
GHS08· Health Hazard
Hazard Statements
H361 Suspected of damaging fertility or the unborn child
H412 Harmful to aquatic life with long lasting effects
Precautionary Statements
P203 Obtain, consult and follow expert instructions for use.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P318 IF exposed or concerned, get medical advice.
P405 Store locked up.
P501 Dispose of contents/container in accordance with local regulations.
Which trade and regulatory codes apply to Valsartan?
HS Code 29339900
Storage Class 11 - Combustible Solids
WGK (Germany) 3