Hydrochlorothiazide
CAS Number
58-93-5
EC Number
200-403-3
Abbreviation
HCTZ
Industries: Pharma & Healthcare
What is Hydrochlorothiazide?
Hydrochlorothiazide (CAS 58-93-5), commonly abbreviated as HCTZ, is a thiazide diuretic active pharmaceutical ingredient used to treat hypertension and edema.
Where is Hydrochlorothiazide used?
- Pharmaceutical manufacturing: antihypertensive API in standalone formulations and fixed-dose combinations
- Oral solid dosage forms: active ingredient in tablets and capsules for cardiovascular and renal indications
- Fixed-dose combinations with ACE inhibitors, ARBs, or beta-blockers
- Generic manufacturers use it as a finished API for direct compression or wet granulation.
- Contract formulators use it as a reference standard component in bioequivalence and analytical method development.
Commercial specifications
- Micronized grades for particle size control
Other Names (Synonyms)
chlorsulfonamidodihydrobenzothiadiazine dioxide|6-chloro-1,1-dioxo-3,4-dihydro-2H-1λ6,2,4-benzothiadiazine-7-sulfonamide|3,4-dihydrochlorothiazide|Esidrix|HCTZ|Vetidrex|2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-, 1,1-dioxide|Su 5879
What are the physical properties of Hydrochlorothiazide?
Melting Point 273-275 °C
Boiling Point 577.0±60.0 °C(Predicted)
Density 1.512 g/cm³ (Liquid)
Flash Point 9°C
Appearance White Solid
Color White to Off-White
Odor wh. or pract. wh. cryst. powd., odorless
Form solid
Water Solubility 722mg/L(25 ºC)
Refractive Index 1.6100 (estimate)
Log P -0.070
How is Hydrochlorothiazide classified and handled safely? Learn More
Danger
GHS07· Irritant GHS08· Health Hazard
Hazard Statements
H302 Harmful if swallowed
H317 May cause an allergic skin reaction
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled
H372 Causes damage to organs through prolonged or repeated exposure
Precautionary Statements
P233 Keep container tightly closed.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash … thoroughly after handling.
Which trade and regulatory codes apply to Hydrochlorothiazide?
HS Code 29350090
UN Number 1230
ADR Class 3
Packing Group II
Storage Class 11 - Combustible Solids
WGK (Germany) 2