Quinine hydrochloride

Quinine hydrochloride (CAS 130-89-2), also known as Quinine HCl, is the salt form of quinine derived from cinchona bark alkaloids. It is used primarily in pharmaceutical manufacturing as an active ingredient and intermediate. Its water solubility makes it the preferred form over quinine base for oral and injectable dosage development. In pharmaceutical manufacturing, Quinine HCl is formulated into tablets, capsules, and injectable solutions.

These formulations target malaria treatment and fever management across various clinical settings. The food and beverage industry sources it under FEMA 2976 as a bittering agent in tonic waters and carbonated soft drinks. Precise dosing controls the characteristic bitter taste profile required for these beverages. It also appears in topical and oral formulations developed for nocturnal leg cramp management in select regulated markets.

Compounding pharmacies use it as a starting material when preparing customized dosage forms requiring defined quinine salt concentrations. Quinine hydrochloride is supplied as a white crystalline powder in anhydrous form. Standard grades include USP, BP, and Ph. Eur., supporting procurement for regulated pharmaceutical and food applications. Bulk quantities are available for industrial buyers and R&D customers.