Berberine hydrochloride

Berberine hydrochloride (CAS 633-65-8), also sold as berberine chloride and known in colorant contexts as Natural Yellow 18, is a plant-derived alkaloid salt extracted primarily from Berberis and Coptis species.

Where is Berberine hydrochloride used?

• Dietary supplements: salt form for capsule and tablet production, with improved solubility over the free base
• Functional food and nutraceuticals: blood glucose and lipid management
• Personal care: antimicrobial and antioxidant active
• Topical formulations: skin-clarifying creams and serums
• Biotechnology and life sciences: reference standard and research reagent for assay development and cell biology studies
• It serves as a bioactive botanical ingredient with metabolic and antimicrobial activity.

Good to know: The salt form is preferred over the free base for capsule and tablet production because of its improved solubility.

Commercial specifications

• High-purity grades typically 97–99% by HPLC
• Bulk supply in kilogram and metric-ton quantities
• Material commonly accompanied by CoA documentation for regulated markets