Thiamine hydrochloride

CAS Number
67-03-8
EC Number
200-641-8
Chemical Formula
C12H17N4OS.ClH.Cl
Molecular Weight
337.3 g/mol
FEMA Number
FEMA 3322

Description

Thiamine hydrochloride (CAS 67-03-8), also known by its FEMA 3322 designation, is the stable salt form of vitamin B1 used across pharmaceutical, food, and cosmetic manufacturing. It functions as a nutritional fortifier and process stabilizer, enabling manufacturers to deliver consistent B1 potency in finished products. In pharmaceutical manufacturing, it is the preferred active ingredient.

This compound is used in oral tablets, injectables, and multivitamin formulations due to its high water solubility and stable shelf life. Food and beverage producers use it to fortify breakfast cereals and flour. It is also essential for infant formula and energy drinks to meet regulatory nutritional labeling requirements. In flavor applications, it serves as a precursor in Maillard reaction systems.

This process generates meat-like and savory flavor profiles in processed food production. Personal care formulators incorporate it into scalp treatments and hair care products targeting enrichment claims. Thiamine hydrochloride is supplied as a white crystalline powder in packaging ranging from kilogram bags to bulk metric ton quantities. It is available in USP, BP, and Ph. Eur. specifications.

These grades meet the compliance requirements of different regulated markets. FCC-grade material is standard for food and beverage fortification applications to ensure high safety standards.

Other Names (Synonyms)

thiaminium chloride hydrochloride|thiamine(2+) dichloride|thiamine HCl|thiamine dichloride|thiamine chloride hydrochloride|Aneurine hydrochloride|Vitamin B1 hydrochloride|Eskaphen

Key Technical Features

  • High Purity Grade standard
  • Consistent Batch Quality
  • Full Regulatory & REACH Support
  • Global Logistics Network enabled

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Physical Properties

Melting Point 248 °C (decomp)
Density 1.3766 (rough estimate)
Flash Point 9°C
Appearance White crystalline powder
Color White to almost white
Odor sour mild bitter
Form Crystalline Powder
Water Solubility 1 g/mL
Refractive Index 1.6000 (estimate)
pH 2.7-3.3
Log P -3.93

Safety & Handling (Learn More)

Warning
GHS07· Irritant

Hazard Statements

H319 Causes serious eye irritation

Precautionary Statements

P280 Wear protective gloves/protective clothing/eye protection/face protection.
P264+P265 Wash … thoroughly after handling.
P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code 29362200
UN Number 1230
Packing Group II
Storage Class 11 - Combustible Solids
WGK (Germany) 1

Documentation

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