Vitamin B1 Thiamine Pyrophosphate (TPP)

Thiamin Diphosphate (CAS 154-87-0), also known as Cocarboxylase and abbreviated as TPP, is the biologically active coenzyme form of Vitamin B1; unlike standard thiamine salts, it is the phosphorylated form.

Where is Vitamin B1 Thiamine Pyrophosphate (TPP) used?

• Pharmaceutical and nutraceutical manufacturing: active ingredient
• Injectable formulations and specialty supplements for metabolic support
• Biotechnology and life sciences: cofactor in enzymatic assay systems and cell culture media
• In vitro diagnostic reagents requiring direct coenzyme activity
• Cosmetic skin-conditioning preparations where the phosphorylated B1 form is preferred for bioavailability
• It also serves as a reference standard and process reagent in enzyme kinetics research and fermentation process development.

Good to know: Unlike standard thiamine salts, it is the phosphorylated form. Standard grades include pharmaceutical-grade material meeting USP and Ph. Eur. specifications.

Commercial specifications

• Pharmaceutical-grade material meeting USP and Ph. Eur. specifications
• Research-grade material for laboratory and biotechnology use
• Bulk quantities for industrial pharmaceutical production and smaller pack sizes for laboratory procurement