Triphenylphosphine

CAS Number
603-35-0
EC Number
210-036-0
Chemical Formula
C18H15P
Molecular Weight
262.3 g/mol
Abbreviation
TPP

Description

Triphenylphosphine (CAS 603-35-0), commonly abbreviated as TPP, is a phosphorus-based ligand and reagent used across pharmaceutical synthesis, polymer stabilization, and specialty chemical manufacturing. It functions primarily as a catalyst component, reducing agent, and stabilizer precursor in demanding industrial processes. In pharmaceutical manufacturing, TPP is a key reagent in Mitsunobu and Wittig reactions.

This material enables stereoselective synthesis of active pharmaceutical ingredients at scale. Polymer producers incorporate it as a processing stabilizer and catalyst precursor in polyester and polyurethane systems. In these applications, it controls oxidative degradation during high-temperature compounding. Printing ink and packaging formulators use TPP-derived systems as photoinitiator components and stabilizers.

These additives extend the service life of UV-curable coatings. In specialty catalyst systems, it acts as a ligand for palladium, rhodium, and other transition metals, supporting cross-coupling reactions. Such reactions are critical to fine chemical production. Triphenylphosphine is supplied as a white crystalline powder and is available in technical grade for industrial catalyst and polymer applications.

It is also offered in high-purity grades meeting pharmaceutical manufacturing requirements. Packaging options typically range from kilogram-scale bags to bulk drum quantities to suit various needs. These formats support both R&D and production-scale procurement. Our logistics network ensures reliable delivery of this essential phosphorus-based reagent for your specific industrial requirements.

Other Names (Synonyms)

Phosphine, triphenyl-|PP 360|TPP

Key Technical Features

  • High Purity Grade standard
  • Consistent Batch Quality
  • Full Regulatory & REACH Support
  • Global Logistics Network enabled

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Physical Properties

Melting Point 80.5 °C
Boiling Point >360 °C
Density 1.075 g/cm³ @ Temp: 80 °C
Flash Point 181 °C
Appearance White, crystalline solid. Insoluble inwater; slightly soluble in alcohol; soluble in benzene, acetone, carbon tetrachloride. Combustible.
Color White
Odor odorless
Form Crystals, Crystalline Powder or Flakes
Water Solubility Insoluble
Vapor Pressure 5 mm Hg ( 20 °C)
Refractive Index 1.6358

Documentation

Safety & Handling Learn More

Danger
GHS05· Corrosive GHS07· Irritant GHS08· Health Hazard

Hazard Statements

H302 Harmful if swallowed
H315 Causes skin irritation
H317 May cause an allergic skin reaction
H318 Causes serious eye damage

Precautionary Statements

P203 Obtain, consult and follow expert instructions for use.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash … thoroughly after handling.

Trade & Regulatory

HS Code 29310095
Storage Class 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects
WGK (Germany) 2
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