Coenzyme B12

Coenzyme B12 (CAS 13870-90-1), also known as adenosylcobalamin, is the biologically active coenzyme form of vitamin B12 used in pharmaceutical, nutraceutical, and cosmetic formulations. Unlike synthetic precursor forms, it is recognized directly by cellular enzymatic pathways, making it a preferred active ingredient where bioavailability is a sourcing priority for manufacturers.

In pharmaceutical and nutraceutical manufacturing, it is incorporated into oral supplements, sublingual tablets, and injectable preparations targeting B12 deficiency and neurological support. Cosmetic formulators use it in anti-aging and skin-conditioning products, where its role in cellular metabolism supports claims around skin renewal and moisture retention in topical applications.

Food and beverage producers apply it in functional nutrition formats, including fortified drinks and dietary supplements, where an active cobalamin form is specified over cyanocobalamin. It also appears in specialized clinical nutrition products where the coenzyme form is required by formulation specification. The material is supplied as a fine crystalline powder for easy blending.

Standard grades include pharmaceutical-grade (USP/BP-aligned) and food-grade specifications to meet regulatory requirements across target markets and international safety standards. Bulk quantities are available alongside smaller research and development quantities for formulation trials. It is typically stored in light-protected packaging due to its inherent photosensitivity.