Vitamin B12 Methylcobalamin

Methylcobalamin (CAS 13422-55-4), also known as MeB12, is the bioactive, coenzyme form of vitamin B12 used as an active pharmaceutical ingredient in neurological and nutritional supplement formulations.

Where is Vitamin B12 Methylcobalamin used?

• Pharmaceutical manufacturing: oral tablets, sublingual preparations and injectable solutions for peripheral neuropathy, cognitive support and B12 deficiency
• Nutraceuticals: high-potency B-complex supplements and combination neurological formulas
• Cosmetics and personal care: topical serums and scalp treatments positioned around skin renewal and hair health
• Contract manufacturers source it as an intermediate for combination API blends in prescription neuropathy products.
• Serves as a reference standard in qualitative, quantitative and methodological research experiments employing HPLC, GC and MS.

Good to know: Unlike synthetic cyanocobalamin, it is the form directly utilized in human metabolism.

Typical specification

• Purity specification of 97.0% to 102.0% (as Vitamin B12).
• Fully soluble in water.
• Appearance is dark red to dark brown crystals or powder.
• Analytical standard grade is available on the market.

Regulatory status

• Water hazard class (WGK) of 2.
• In Turkish food supplement regulations, the allowed B12 sources are cyanocobalamin and hydroxocobalamin, not methylcobalamin.

Storage, packaging and handling

• Recommended storage temperature is -20°C.
• Should be stored sealed, dry, and protected from light.

Frequently asked questions about Vitamin B12 Methylcobalamin

What is the physical form and color of methylcobalamin?

Methylcobalamin is a form of Vitamin B12 with a dark red crystalline or amorphous powder appearance.

What is the difference between methylcobalamin and Vitamin B12 1% premix?

Vitamin B12 1% is a premix grade blended with a carrier for lower potency and easier dosing.

Technical content is compiled and updated by the SoleChem product team from public technical sources; the certificate of analysis (COA) governs product-specific specifications.