L-methionine

L-Methionine (CAS 63-68-3), commonly abbreviated as Met, is an essential sulfur-containing amino acid that the human body cannot synthesize and must obtain through diet or supplementation.

Where is L-methionine used?

• Animal nutrition: corrects methionine deficiency and improves feed conversion ratios in poultry, swine and aquaculture feeds
• Pharmaceuticals: active ingredient in amino acid infusion solutions and tablet formulations for liver support and metabolic health
• Food: fortifies protein supplements, clinical nutrition products and functional foods
• Personal care: humectant and antioxidant in skin and hair formulations
• In industry it functions as a nutritional fortifier, antioxidant stabilizer and precursor compound.
• Suitable for injectable biologic and vaccine formulations.
• Directly reacts with and neutralizes reactive oxygen species such as superoxide anion and hydroxyl radicals, preventing oxidative damage to monoclonal antibodies.

Formulation notes

• A level of 0.1 to 0.2% in poultry feed strongly changes metabolism and growth curve.

Typical specification

• Sold with a titration purity of 99.0-101.0% on a dried basis.
• Water solubility is 25 mg/mL.
• Offered in a cell culture reagent grade.
• Offered in a parenteral excipient grade manufactured under cGMP.

Storage, packaging and handling

• Should be stored at room temperature.

Frequently asked questions about L-methionine

What pharmaceutical applications does L-methionine have?

It is used as an antidote for acetaminophen poisoning and as a urinary acidifier.

How does L-methionine act as an antioxidant in monoclonal antibody formulations?

It can chelate transition metal ions such as iron and copper, inhibiting their ability to generate reactive oxygen species, and can regenerate other antioxidants such as glutathione and vitamin E, enhancing the overall antioxidant capacity of monoclonal antibody formulations.

Technical content is compiled and updated by the SoleChem product team from public technical sources; the certificate of analysis (COA) governs product-specific specifications.