L-cysteine

CAS Number
52-90-4
EC Number
200-158-2
E Number
E914
FEMA Number
FEMA 3263
Abbreviation
Cys

What is L-cysteine?

L-Cysteine (CAS 52-90-4), also designated E920 in food applications, is a sulfur-containing amino acid sourced through fermentation or protein hydrolysis.

Where is L-cysteine used?

  • Food and pharmaceutical manufacturing: dough conditioner and antioxidant
  • Precursor in flavor and nutrient synthesis
  • Commercial baking: E920 reduces mixing time and improves dough extensibility in bread, crackers, and pizza bases
  • Pharmaceutical and nutraceutical: building block for glutathione synthesis and amino acid infusion formulations
  • Personal care: hair treatment products
  • Keratin-based straightening and conditioning systems where it modifies disulfide bonds in hair protein
  • In flavor production, Cys reacts with sugars under heat to generate meat-like and savory Maillard compounds.

Good to know: Qualifies under FEMA 3263 for reaction flavor systems. The hydrochloride salt is the most commercially prevalent form due to its stability and ease of handling in industrial settings.

Commercial specifications

  • Free base and hydrochloride monohydrate forms
  • Grades: USP, Ph. Eur., FCC, food-grade

Other Names (Synonyms)

(2R)-2-ammonio-3-sulfanylpropanoate|L-Zystein|L-Cystein|L-Cys|L-2-Amino-3-mercaptopropionic acid|L-2-Amino-3-mercaptopropanoic acid|L-2-Amino-3-mercaptopropanoate|Half-cystine|Cys|E920

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What are the physical properties of L-cysteine?

Melting Point 240 °C (decomp)
Boiling Point 293.9±35.0 °C(Predicted)
Density 1.6666 g/cm³ @ Temp: 45.00 °C
Appearance White crystalline powder
Color White
Odor sulfury
Form Solid
Water Solubility 280 g/L (25 ºC)
Refractive Index 8.8 ° (C=8, 1mol/L HCl)
pH 4.5-5.5 (100g/l, H2O, 20℃)
Log P -2.49

How is L-cysteine classified and handled safely? Learn More

Warning
GHS07· Irritant

Hazard Statements

H302 Harmful if swallowed
H315 Causes skin irritation
H319 Causes serious eye irritation
H335 May cause respiratory irritation

Precautionary Statements

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash … thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.

Which trade and regulatory codes apply to L-cysteine?

HS Code 29309012
Storage Class 11 - Combustible Solids
WGK (Germany) 3
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