n-acetyl-L-cysteine

CAS Number
616-91-1
EC Number
210-498-3
Chemical Formula
C5H9NO3S
Molecular Weight
163.20 g/mol
Abbreviation
NAC

Description

N-Acetyl-L-Cysteine (CAS 616-91-1) is a stabilized, acetylated form of the amino acid cysteine used as an antioxidant and mucolytic agent across pharmaceutical, nutraceutical, and cosmetic manufacturing. Mercapturic acid is a recognized biochemical synonym occasionally referenced in technical literature. NAC functions primarily as a glutathione precursor and reducing agent, making it a sought-after active ingredient.

In pharmaceutical manufacturing, NAC is the active ingredient in mucolytic drug products such as effervescent tablets, oral solutions, and inhalation formulations targeting various respiratory conditions. Nutraceutical and dietary supplement producers use it as an antioxidant active in capsules, powders, and functional beverages positioned around cellular protection and detoxification support.

In cosmetic formulations, NAC acts as a reducing agent in hair waving and straightening treatments, breaking disulfide bonds in keratin to reshape the hair structure effectively. Food manufacturers also apply it as a dough conditioner, where it reduces gluten network strength to improve machinability in cracker and biscuit production for industrial food processing.

NAC is supplied as a white crystalline powder. Pharmaceutical-grade material is available to USP, BP, and Ph. Eur. specifications, meeting the purity and testing requirements for drug product use. Food-grade supply conforming to FCC standards is available for nutrition and food processing applications. This ensures the material meets the rigorous safety standards required for global distribution.

Other Names (Synonyms)

N-acetylcysteine|N-acetyl-3-mercaptoalanine|mercapturic acid|L-α-acetamido-β-mercaptopropionic acid|L-alpha-acetamido-beta-mercaptopropionic acid|L-acetylcysteine|2-acetylamino-3-mercaptopropionic acid|2-acetylamino-3-mercaptopropionate|NAC

Key Technical Features

  • High Purity Grade standard
  • Consistent Batch Quality
  • Full Regulatory & REACH Support
  • Global Logistics Network enabled

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Physical Properties

Melting Point 109.5 °C
Boiling Point 407.7±40.0 °C(Predicted)
Density 1.249 (estimate)
Appearance White crystalline powder
Color White
Form Solid
Water Solubility Soluble in water, ethanol, methanol, dimethyl sulfoxide, hot isopropyl alcohol, methyl acetate and ethyl acetate. Insoluble in chloroform and ether.
Vapor Pressure 0Pa at 20℃
Refractive Index 24 ° (C=JPC Method)
pH 1.5-2.5 (20°C, 100g/L in H2O)
Log P -0.6 at 23℃

Safety & Handling (Learn More)

Warning
GHS07· Irritant

Hazard Statements

H319 Causes serious eye irritation

Precautionary Statements

P280 Wear protective gloves/protective clothing/eye protection/face protection.
P264+P265 Wash … thoroughly after handling.
P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code 29309016
WGK (Germany) 3

Documentation

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