n-acetyl-L-glutamic acid

N-Acetyl-L-Glutamic Acid (CAS 1188-37-0), also known as NAG, is an acetylated derivative of L-glutamic acid used as a biochemical intermediate and functional ingredient across pharmaceutical and personal care applications. It acts as a pH buffer and moisture-retaining agent in formulations where precise ionic balance and skin compatibility are required. In pharmaceutical manufacturing, NAG serves as a key intermediate in the synthesis of active compounds.

It is used in parenteral and oral formulation development where buffering capacity must be tightly controlled. Cosmetic formulators incorporate it into moisturizing serums, creams, and skin-conditioning products for its hygroscopic character. Its unique properties support water retention in the stratum corneum. It is also evaluated in amino acid-based infusion solutions and nutraceutical preparations targeting metabolic support pathways for various health applications.

Research-grade applications include use as a biochemical reagent in enzyme activity studies and metabolic pathway investigations. N-Acetyl-L-Glutamic Acid is supplied as a white crystalline powder for industrial use. Pharmaceutical-grade material is available to USP and BP specifications, supporting use in regulated drug product manufacturing. Technical and research-grade quantities are also offered for industrial synthesis.