L-serine

CAS Number
56-45-1
EC Number
200-274-3

What is L-serine?

L-Serine (CAS 56-45-1) is a non-essential amino acid used in food, pharmaceutical, and cosmetic manufacturing as a functional ingredient and formulation component. Also designated L-Ser and Serinum.

Where is L-serine used?

  • Nutraceuticals and dietary supplements: amino acid blends, protein fortification systems, cognitive health formulations
  • Pharmaceuticals: precursor and stabilizing excipient in injectable solutions and infusion fluids
  • Cosmetics: humectant in skin-conditioning serums, moisturizing creams, and leave-on treatments
  • Food and beverage: pH buffering and antioxidant stabilization
  • It supports moisture retention, buffering, and stability.

Good to know: Pharmaceutical-grade material is subject to stricter purity and residue specifications. Grades include USP, Ph. Eur., food-grade (FCC), BP, EP, and ACS.

Commercial specifications

  • Highly soluble in water
  • Stable under standard processing conditions
  • Bulk quantities for industrial formulation; smaller quantities for R&D and quality assurance

Other Names (Synonyms)

Serinum|L-Serin|L-Ser|L-3-Hydroxy-alanine|L-3-Hydroxy-2-aminopropionic acid|L-3-Hydroxy-2-aminopropionate|L-2-Amino-3-hydroxypropionic acid|beta-Hydroxyalanine

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What are the physical properties of L-serine?

Melting Point 228 °C (decomp)
Boiling Point 197.09°C (rough estimate)
Density 1.6 g/cm³ @ Temp: 22 °C
Flash Point 150°C
Appearance White crystalline powder
Color White
Odor wh. cryst. or cryst. powd., odorless, sweet taste
Form powder
Water Solubility 250 g/L (20 ºC)
Refractive Index 1.4368 (estimate)
pH 5-6 (100g/l, H2O, 20℃)
Log P -1.580

Which trade and regulatory codes apply to L-serine?

HS Code 29225000
Storage Class 11 - Combustible Solids
WGK (Germany) 3
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