L-tyrosine

CAS Number
60-18-4
EC Number
200-460-4
FEMA Number
FEMA 3736
Abbreviation
Tyr

What is L-tyrosine?

L-Tyrosine (CAS 60-18-4), commonly abbreviated as Tyr, is a conditionally essential amino acid sourced through both fermentation and chemical synthesis for commercial supply.

Where is L-tyrosine used?

  • Pharmaceuticals: bioactive building block, active ingredient and synthesis intermediate
  • Thyroid-related compounds and specialty APIs
  • Dietary supplements and functional nutrition: capsules, powders and sports nutrition blends for cognitive and physical performance support
  • Food: flavor development in aged cheeses and fermented products
  • Cosmetics: skin-brightening and melanin-modulating topical products acting on pigmentation pathways
  • It is formulated into capsules, powders and sports nutrition blends.
  • Used in cosmetics, such as tanning accelerators and skin care products, as a precursor of melanin.
  • Used in pharmaceutical production as an API or excipient in parenteral and oral preparations.
  • Due to limited water solubility, best used in capsules, tablets, or powder blends where complete dissolution is not required, or in acidic beverages where solubility improves.
  • After an aminocarbonyl hot reaction with sugars, can generate special flavor substances.

Good to know: FEMA 3736 applies to its flavoring use. Established grades include USP, BP and Ph. Eur., with FCC-grade material for food and flavoring use.

Typical specification

  • Assay content is 99 to 101.5%.
  • Sold in powder and crystal form.
  • Solubility increases in acidic or basic solutions due to ionization of its amino and carboxyl groups.

Storage, packaging and handling

  • Should be stored in a cool, dry place without direct sunlight.
  • Commonly packed in 25 kg drums.

Frequently asked questions about L-tyrosine

What is the solubility profile of L-tyrosine in water and ethanol?
L-tyrosine is soluble in water and poorly soluble in ethanol.

Technical content is compiled and updated by the SoleChem product team from public technical sources; the certificate of analysis (COA) governs product-specific specifications.

Other Names (Synonyms)

4-hydroxy-L-phenylalanine|(S)-α-amino-4-hydroxybenzenepropanoic acid|(S)-tyrosine|(S)-alpha-amino-4-hydroxybenzenepropanoic acid|(S)-3-(p-hydroxyphenyl)alanine|(S)-2-amino-3-(p-hydroxyphenyl)propionic acid|(2S)-2-azanyl-3-(4-hydroxyphenyl)propanoic acid|(2S)-2-amino-3-(4-hydroxyphenyl)propionic acid|Tyr

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What are the physical properties of L-tyrosine?

Melting Point 344 °C
Boiling Point 314.29°C (rough estimate)
Density 0.01600 mol/L
Flash Point 176 °C
Appearance White to off-white powder
Color White to Pale-brown
Odor odorless
Form powder
Water Solubility 0.45 g/L (25 ºC)
Refractive Index -12 ° (C=5, 1mol/L HCl)
pH 6.5 (0.1g/l, H2O)
Log P 0.38

How is L-tyrosine classified and handled safely? Learn More

Warning
GHS07· Irritant

Hazard Statements

H315 Causes skin irritation
H319 Causes serious eye irritation
H335 May cause respiratory irritation

Precautionary Statements

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash … thoroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.

Which trade and regulatory codes apply to L-tyrosine?

HS Code 29225000
WGK (Germany) 3
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