Amino Acids & Peptides
REACH
L-histidine
CAS Number
71-00-1
EC Number
200-745-3
FEMA Number
FEMA 3694
Abbreviation
His
What is L-histidine?
L-Histidine (CAS 71-00-1), abbreviated His, is a proteinogenic amino acid used in pharmaceutical, nutritional and cosmetic manufacturing.
Where is L-histidine used?
- Pharmaceutical and biopharmaceutical: buffering agent and stabilizer in monoclonal antibody and protein drug formulations, maintaining pH stability and protecting against aggregation during storage
- Nutritional supplements: active ingredient in amino acid blends, sports nutrition and clinical nutrition formulas for muscle recovery and metabolic support
- Food: flavour precursor (FEMA 3694) contributing savoury and meat-like taste profiles in processed and seasoned products
- Cosmetics: humectant and antioxidant stabilizer in skin care, protecting active ingredients from oxidative degradation
- It also serves as a nutritional building block in finished formulations.
Good to know: Pharmaceutical grades are the most commonly specified for injectable and parenteral applications.
Commercial specifications
- Free base and monohydrochloride salt forms
- Bulk supply in kilogram and metric ton quantities
Other Names (Synonyms)
(2S)-2-azaniumyl-3-(1H-imidazol-4-yl)propanoate|L-Histidin|L-His|Histidina|(S)-α-amino-1H-Imidazole-4-propanoic acid|(S)-alpha-Amino-1H-imidazole-4-propionic acid|(S)-alpha-amino-1H-Imidazole-4-propanoic acid|(S)-a-Amino-1H-imidazole-4-propanoic acid|His
What are the physical properties of L-histidine?
Melting Point 287 °C (decomp)
Boiling Point 278.95°C (rough estimate)
Density 1.309 g/cm³
Appearance White crystalline powder
Color White to off-white or pale yellow
Odor odorless
Form powder
Water Solubility 41.6 g/L (25 ºC)
Refractive Index 13 ° (C=11, 6mol/L HCl)
pH 7.0-8.0 (25℃, 0.1M in H2O)
Log P -1.27
How is L-histidine classified and handled safely? Learn More
Warning
GHS07· Irritant
Hazard Statements
H302 Harmful if swallowed
H315 Causes skin irritation
H319 Causes serious eye irritation
H332 Harmful if inhaled
Precautionary Statements
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash … thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
Which trade and regulatory codes apply to L-histidine?
HS Code 29332990
Storage Class 11 - Combustible Solids
WGK (Germany) 2