L-hydroxyproline

CAS Number
51-35-4
EC Number
200-091-9
Abbreviation
Hyp

What is L-hydroxyproline?

L-Hydroxyproline (CAS 51-35-4), commonly abbreviated as Hyp, is a non-essential amino acid derived primarily from collagen hydrolysis.

Where is L-hydroxyproline used?

  • Biochemical marker for collagen content and building block in peptide synthesis
  • Pharmaceutical manufacturing: reference standard and synthetic intermediate for collagen-related peptides and drug compounds targeting connective tissue
  • Nutraceutical formulations and cosmetic actives development
  • Food and nutrition: collagen-based supplements, functional protein blends and hydrolyzed collagen products requiring amino acid profile verification
  • Personal care: moisturizing and stabilizing agent in anti-aging creams, serums and skin-conditioning treatments with collagen support claims
  • It serves as an analytical reagent in quality control laboratories for quantifying collagen content in raw materials and finished products.

Commercial specifications

  • Bulk quantities standard; smaller quantities for R&D and QC

Other Names (Synonyms)

trans-L-Hydroxyproline|trans-Hydroxyproline|trans-4-Hydroxyproline|LS-hydroxyproline|L-4-Hydroxyproline|Hypro|Hyp|Hydroxy-proline

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What are the physical properties of L-hydroxyproline?

Melting Point 274 °C
Boiling Point 242.42°C (rough estimate)
Density 1.478 g/cm³
Appearance White crystalline powder
Color White
Odor Odorless
Form Crystals or Crystalline Powder
Water Solubility 357.8 g/L (20 º C)
Refractive Index -75.5 ° (C=4, H2O)
pH 5.5-6.5 (50g/l, H2O, 20℃)
Log P -0.350 (est)

How is L-hydroxyproline classified and handled safely? Learn More

Warning
GHS07· Irritant

Hazard Statements

H315 Causes skin irritation
H319 Causes serious eye irritation
H335 May cause respiratory irritation

Precautionary Statements

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash … thoroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.

Which trade and regulatory codes apply to L-hydroxyproline?

HS Code 29339990
Storage Class 11 - Combustible Solids
WGK (Germany) 3
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