trans-5-hydroxy-L-pipecolic acid

Trans-5-hydroxy-L-pipecolic acid (CAS 50439-45-7) is a hydroxylated cyclic amino acid used as a reference standard and building block in pharmaceutical and biotechnology research. It supports pH regulation and buffering in specialized formulations where precise chemical characterization is required.

In pharmaceutical development, it serves as an analytical reference standard for method validation, impurity profiling, and quality control of amino acid-related drug substances. Peptide chemists use it as a chiral building block in the synthesis of constrained peptidomimetics.

The compound is essential for the development of bioactive cyclic peptide scaffolds. Biotechnology researchers employ it in metabolic studies and biosynthetic pathway investigations, particularly in work related to natural product biosynthesis.

Its defined stereochemistry makes it a preferred reagent for asymmetric synthesis programs requiring enantiomerically pure cyclic amino acid inputs. This ensures high precision in complex chemical reactions and research applications.

Trans-5-hydroxy-L-pipecolic acid is supplied as a white to off-white crystalline powder. It is available primarily in research and catalog quantities, with purity specifications typically at 98% or higher by HPLC analysis.

Supply is sourced through fine chemical and specialty amino acid suppliers catering to pharmaceutical and life sciences procurement. The material meets rigorous internal quality benchmarks to ensure consistency across various laboratory and industrial batches.