trans-5-hydroxy-L-pipecolic acid

Trans-5-hydroxy-L-pipecolic acid (CAS 50439-45-7) is a hydroxylated cyclic amino acid used as a reference standard and building block in pharmaceutical and biotechnology research.

Where is trans-5-hydroxy-L-pipecolic acid used?

• Pharmaceutical development: analytical reference standard for method validation, impurity profiling and quality control of amino acid-related drug substances
• Peptide chemistry: chiral building block for constrained peptidomimetics
• Development of bioactive cyclic peptide scaffolds
• Biotechnology: metabolic studies and biosynthetic pathway investigations, particularly natural product biosynthesis
• Asymmetric synthesis programmes requiring enantiomerically pure cyclic amino acid inputs, its defined stereochemistry makes it a preferred reagent
• It supports pH regulation and buffering in specialised formulations requiring precise chemical characterisation.

Commercial specifications

• Purity typically 98% or higher by HPLC
• Research and catalog quantities