Histidine monohydrochloride monohydrate

Histidine monohydrochloride monohydrate (CAS 5934-29-2), also supplied as L-histidine hydrochloride, is the stabilized salt form of the essential amino acid L-histidine. Its hydrated, water-soluble structure makes it the preferred form for buffering and stabilizing sensitive formulations.

This compound is essential for buffering across pharmaceutical, nutritional, and cosmetic manufacturing. In biopharmaceutical manufacturing, it functions as a primary buffer component in monoclonal antibody and protein drug formulations.

Precise pH control directly impacts product stability and shelf life in these applications. Parenteral and injectable drug products rely on this grade to maintain formulation integrity during freeze-drying and long-term storage.

In food and nutritional supplement production, it is used as an amino acid fortifier in clinical nutrition products. It is also a key ingredient in infant formula and sports nutrition blends to ensure proper amino acid profiles.

Cosmetic formulators incorporate it into skin care products for its moisture-retention and antioxidant-stabilizing properties. It is particularly effective in serums and treatment creams targeting sensitive skin types.

Histidine monohydrochloride monohydrate is available as a white crystalline powder. It is commonly supplied in USP, BP, and Ph. Eur. grades to meet pharmaceutical manufacturing requirements.

Food-grade specifications are also available for nutritional applications. Bulk quantities are typically offered in fiber drums or double-lined polyethylene bags to ensure product safety and stability during transport.