Amino Acids & Peptides
REACH
Histidine monohydrochloride monohydrate
CAS Number
5934-29-2
EC Number
611-821-4
What is Histidine monohydrochloride monohydrate?
Histidine monohydrochloride monohydrate (CAS 5934-29-2) is the stabilized salt form of the essential amino acid L-histidine. Also marketed as L-histidine hydrochloride.
Where is Histidine monohydrochloride monohydrate used?
- Biopharmaceutical manufacturing: primary buffer component in monoclonal antibody and protein drug formulations
- Parenteral and injectable drugs: maintains formulation integrity during freeze-drying and long-term storage
- Food and nutritional supplements: amino acid fortifier in clinical nutrition products, infant formula and sports nutrition blends
- Cosmetics: moisture-retention and antioxidant-stabilizing properties in skin care products, serums and treatment creams
- Its hydrated, water-soluble structure makes it the preferred form for buffering and stabilizing sensitive formulations.
Good to know: Precise pH control directly impacts product stability and shelf life.
Commercial specifications
- Bulk quantities in fiber drums or double-lined polyethylene bags
Other Names (Synonyms)
L-histidine hydrochloride|L-histidine monohydrochloride monohydrate|(2S)-2-amino-3-(1H-imidazol-5-yl)propanoic acid;hydrate;hydrochloride|L-histidine hydrochloride monohydrate
What are the physical properties of Histidine monohydrochloride monohydrate?
Melting Point 254 °C (decomp)
Density 1.49 g/cm3
Appearance White crystals or crystalline powder
Color White
Odor odorless
Form Solid
Water Solubility 169.9 g/L (20 ºC)
Vapor Pressure <1 hPa (20 °C)
pH 3.5-4.5 (100g/l, H2O, 20℃)
Log P -3.32 at 25℃
How is Histidine monohydrochloride monohydrate classified and handled safely? Learn More
Warning
GHS07· Irritant
Hazard Statements
H315 Causes skin irritation
H319 Causes serious eye irritation
Precautionary Statements
P264 Wash … thoroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P321 Specific treatment (see … on this label).
P264+P265 Wash … thoroughly after handling.
Which trade and regulatory codes apply to Histidine monohydrochloride monohydrate?
HS Code 29332990
WGK (Germany) 3