Histidine monohydrochloride

Histidine monohydrochloride (CAS 645-35-2), also marketed as Histidine HCl, is the hydrochloride salt form of the essential amino acid L-histidine. Its salt form offers improved solubility and stability compared to the free base. This makes it the preferred form for pharmaceutical manufacturing and precision nutrition applications. In pharmaceutical manufacturing, Histidine HCl is used as a buffering agent in biologic drug formulations.

It is particularly useful for monoclonal antibodies and protein-based injectables, where it stabilizes pH and protects active compounds during storage. Parenteral nutrition solutions incorporate it as a source of this amino acid. This supports patients unable to meet requirements through oral intake. In sports nutrition and clinical dietary products, it is used to fortify amino acid blends and medical foods targeting muscle recovery.

Animal feed applications include supplementation of poultry and aquaculture diets where histidine is a limiting amino acid affecting growth performance. It is available as a white crystalline powder. Standard grades include USP, BP, and food-grade (FCC), with pharmaceutical-grade material subject to strict purity and endotoxin specifications. Bulk supply is typically offered in large quantities.

We provide kilogram to metric-ton quantities to serve both R&D and commercial-scale procurement needs. This ensures a reliable supply chain for global manufacturers across the life sciences and food sectors.