Histidine monohydrochloride

Histidine monohydrochloride (CAS 645-35-2), also marketed as Histidine HCl, is the hydrochloride salt form of the essential amino acid L-histidine.

Where is Histidine monohydrochloride used?

• Pharmaceutical manufacturing: buffering agent in biologic drug formulations
• Monoclonal antibodies and protein-based injectables: stabilizes pH and protects active compounds during storage
• Parenteral nutrition: amino acid source for patients unable to meet requirements through oral intake
• Sports nutrition and clinical dietary products: fortifies amino acid blends and medical foods targeting muscle recovery
• Animal feed: supplementation of poultry and aquaculture diets where histidine is a limiting amino acid affecting growth performance

Good to know: Its salt form offers improved solubility and stability compared to the free base, making it the preferred form for pharmaceutical manufacturing and precision nutrition.

Commercial specifications

• Pharmaceutical-grade material subject to strict purity and endotoxin specifications
• Bulk supply in kilogram to metric-ton quantities for R&D and commercial-scale procurement