L-5-Hydroxytryptophan

CAS Number
4350-09-8
EC Number
224-411-1
Chemical Formula
C11H12N2O3
Molecular Weight
220.22 g/mol
Abbreviation
5-HTP

Description

L-5-Hydroxytryptophan (CAS 4350-09-8), commonly known as 5-HTP and commercially sourced as Oxitriptan or Griffonia Seed Extract, is a naturally occurring amino acid precursor used across pharmaceutical, nutraceutical, and functional food manufacturing. It is commercially extracted from the seeds of Griffonia simplicifolia and serves as a direct biosynthetic precursor to serotonin, making it a primary active ingredient in mood and sleep support formulations.

In nutraceutical manufacturing, 5-HTP is the core active in dietary supplement capsules and tablets targeting sleep quality, appetite regulation, and mood balance. Functional food and beverage formulators incorporate it into fortified products. Pharmaceutical-grade material is used in clinical and OTC product development, particularly in markets where Oxitriptan is recognized as an established API. It meets rigorous quality standards for global distribution.

Cosmetic formulators have adopted it in premium skincare lines for its antioxidant activity, positioning it in anti-aging serums and moisturizing treatments. This versatility makes it a valuable raw material for diverse industries. 5-HTP is supplied as a fine white to off-white powder. Standard commercial grades include food-grade and pharmaceutical-grade specifications, with purity levels typically at 98% or higher by HPLC analysis.

Material derived from Griffonia seed extract is the dominant commercial form and is available with supporting documentation for botanical traceability. Our supply chain ensures consistent quality and reliable lead times for bulk orders.

Other Names (Synonyms)

Oxitriptan|Griffonia Seed Extract|Griffonia Seed Extract (5-htp)|(2S)-2-amino-3-(5-hydroxy-1H-indol-3-yl)propanoic acid|5-Hydroxy-L-tryptophan|5-HTP

Key Technical Features

  • High Purity Grade standard
  • Consistent Batch Quality
  • Full Regulatory & REACH Support
  • Global Logistics Network enabled

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Physical Properties

Melting Point 273 °C (decomp)
Boiling Point 361.16°C (rough estimate)
Density 0.902 g/mL at 25 °C(lit.)
Flash Point 175 °F
Appearance white to pale grey powder
Color white
Form solid
Water Solubility Slightly soluble
Refractive Index n 20/D 1.4850(lit.)
Log P -0.140 (est)

Documentation

Safety & Handling Learn More

Danger
GHS06· Toxic GHS07· Irritant

Hazard Statements

H301 Toxic if swallowed
H315 Causes skin irritation
H319 Causes serious eye irritation
H335 May cause respiratory irritation

Precautionary Statements

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash … thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.

Trade & Regulatory

HS Code 29339990
UN Number 2811
ADR Class 6.1
Packing Group III
Storage Class 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects
WGK (Germany) 3
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