5-Hydroxytryptophan

CAS Number
56-69-9
EC Number
200-284-8
Chemical Formula
C11H12N2O3
Molecular Weight
220.22 g/mol
Abbreviation
5-HTP

Description

5-Hydroxytryptophan (CAS 56-69-9), commercially known as 5-HTP, is a naturally occurring amino acid intermediate derived primarily from the seeds of Griffonia simplicifolia. In dietary supplement and nutraceutical manufacturing, it functions as a direct precursor to serotonin. This makes it a target active ingredient for mood, sleep, and appetite-related formulations. Supplement manufacturers use 5-HTP as the primary active in capsule, tablet, and softgel formats targeting sleep support and stress management.

It is also utilized in weight management categories. In functional food and beverage development, it is incorporated into products where serotonin-pathway support is the intended positioning for the final consumer product. Cosmetic and personal care formulators apply it in anti-aging and skin-tone products. Its antioxidant activity supports formulation stability and skin conditioning claims across various topical applications and beauty-from-within solutions.

Pharmaceutical-grade material is used in clinical research and as a reference standard in analytical method development. 5-HTP is supplied as a fine white to off-white powder with high solubility characteristics for diverse manufacturing needs. It is available in food-grade and pharmaceutical-grade specifications, with purity levels typically at 98% or higher confirmed by HPLC. Packaging ranges from small research quantities to bulk commercial volumes for global distribution.

Material is commonly sourced to USP or BP-aligned quality standards to ensure safety and efficacy. Our supply chain ensures consistent potency and rigorous testing for heavy metals and microbiological contaminants in every batch.

Other Names (Synonyms)

5-HTP|DL-5-HTP|Tryptophan, 5-hydroxy-|9181P3OI6N|5-Hydroxytryptophane|Griffonia simplicifolia

Key Technical Features

  • High Purity Grade standard
  • Consistent Batch Quality
  • Full Regulatory & REACH Support
  • Global Logistics Network enabled

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Physical Properties

Melting Point 298 °C (decomp)
Boiling Point 361.16°C (rough estimate)
Density 1.484
Color Off-White to Pale Beige
Form solid
Water Solubility Soluble in water (4 mg/ml at 25°C), methanol.
Refractive Index 1.5200 (estimate)
Log P -0.292 (est)

Documentation

Safety & Handling Learn More

Danger
GHS02· Flammable GHS06· Toxic GHS07· Irritant

Hazard Statements

H226 Flammable liquid and vapor
H301 Toxic if swallowed
H302 Harmful if swallowed
H319 Causes serious eye irritation
H332 Harmful if inhaled

Precautionary Statements

P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
P233 Keep container tightly closed.
P240 Ground and bond container and receiving equipment.
P241 Use explosion-proof [electrical/ventilating/lighting/…] equipment.

Trade & Regulatory

WGK (Germany) 3
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