Yohimbine

Yohimbine (CAS 146-48-5), also known as Johimbin, is an indole alkaloid extracted from the bark of the West African Yohimbe tree.

Where is Yohimbine used?

• Pharmaceutical manufacturing: active substance in prescription and over-the-counter products targeting adrenergic pathways
• QC laboratories: reference standard and analytical reagent validating alkaloid-based drug formulations
• Research institutions and contract manufacturers: intermediate for synthesizing structurally related compounds and pharmacological study tools
• Specialty supplement manufacturers operating under applicable regulatory frameworks procure it for dosage forms.

Good to know: It functions as an alpha-2 adrenergic receptor antagonist. The hydrochloride salt form — yohimbine HCl — is the most commercially prevalent specification.

Commercial specifications

• Pharmaceutical-grade material meeting defined purity thresholds, typically ≥98% by HPLC
• Documentation suitable for USP and BP environments
• High-purity batches comply with ACS specifications