Yohimbine

Yohimbine (CAS 146-48-5), also known as Johimbin, is an indole alkaloid extracted from the bark of the West African Yohimbe tree. It functions as an alpha-2 adrenergic receptor antagonist and is sourced primarily as a pharmaceutical intermediate.

In pharmaceutical manufacturing, it is used as the active substance in prescription and over-the-counter products targeting adrenergic pathways. It serves as a reference standard and analytical reagent in QC laboratories validating alkaloid-based drug formulations.

Research institutions and contract manufacturers source it as an intermediate for synthesizing structurally related compounds and pharmacological study tools. Specialty supplement manufacturers operating under applicable regulatory frameworks also procure it for dosage forms.

The material is supplied as a white to off-white crystalline powder. Standard grades include pharmaceutical-grade material meeting defined purity thresholds, typically ≥98% by HPLC, with documentation suitable for USP and BP environments.

The hydrochloride salt form — yohimbine HCl — is the most commercially prevalent specification. It is available from alkaloid extraction and semi-synthetic production routes to meet EP and Ph.Eur. quality standards.

For laboratory applications, high-purity batches are available that comply with ACS specifications. This ensures consistency and reliability for sensitive analytical procedures and complex chemical synthesis projects.