Cinchonine
Description
Cinchonine (CAS 118-10-5) is a natural cinchona bark alkaloid used across pharmaceutical, biotechnology, and personal care sectors. Commercially recognized as D-Cinchonine, it functions primarily as a chiral resolving agent.
It serves as a biochemical tool compound in synthesis and research workflows. In pharmaceutical manufacturing, it resolves racemic mixtures to isolate enantiomerically pure active ingredients for production.
This is a critical step in API production where chiral purity directly affects regulatory approval. Biotechnology researchers use it as a reference standard and chiral selector in chromatographic method development.
Personal care formulators incorporate it into preservation systems where alkaloid-based antimicrobial activity supports product stability. It also serves research applications in asymmetric catalysis for development.
Its quinuclidine-quinoline scaffold is used to develop organocatalyst systems. The material is supplied as a white to off-white crystalline powder available in reagent-grade and high-purity specifications.
It is suited to pharmaceutical and analytical applications, with select suppliers offering material compliant with reference standard requirements. Packaging ranges from small research quantities to bulk orders.
Industrial-scale chiral resolution processes utilize this compound for its reliable performance. The product meets rigorous industry expectations for consistency and chemical stability in various environments.
Physical Properties
| Melting Point | 265 °C |
| Boiling Point | 436.16°C (rough estimate) |
| Density | 1.0863 (rough estimate) |
| Appearance | white to light yellow crystal powde |
| Color | White to light beige |
| Form | Micro-Crystalline Powder |
| Water Solubility | Insoluble |
| Vapor Pressure | 0Pa at 25℃ |
| Refractive Index | 223 ° (C=0.5, EtOH) |
| pH | 9.0 (0.25g/l, H2O, 20℃)(as aqueous solution) |
| Log P | 2.82 at 25℃ |
Safety & Handling (Learn More)
Trade & Regulatory
| HS Code | 29339900 |
| WGK (Germany) | 3 |
Documentation
Other Names
D-Cinchonine|(9S)-Cinchonan-9-ol|Cinchonan-9-ol, (9S)-|(8R,9S)-Cinchonine|(+)-Cinconine|V43X79NZCD|Cinchonine Alkaloid
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