Rhein
Description
Rhein (CAS 478-43-3), also known as Cassic acid and Rhubarb Yellow, is an anthraquinone compound derived from rhubarb root and related botanical sources. It functions as a natural colorant, antioxidant, and UV-stabilizing agent across pharmaceutical, cosmetic, and industrial applications.
In personal care formulations, it is incorporated as a natural yellow pigment and antioxidant active, particularly in products targeting skin tone evenness and photoprotection. The textile and leather industries use it as a natural dye capable of imparting yellow to orange hues.
This compound is applied to protein-based and cellulosic fibers, often in combination with mordants to improve wash fastness. Pharmaceutical manufacturers source it as a reference standard and active ingredient in preparations derived from traditional botanical extracts.
It contributes to the documented bioactivity of rhubarb-based formulations in various medicinal contexts. In paper processing, it is evaluated as a surface-modifying agent that influences substrate wettability and coating adhesion for specialized industrial uses.
The material is supplied as a yellow to orange crystalline powder for ease of handling. It is available in research-grade and pharmaceutical-grade specifications, with purity levels typically ranging from 95% to 98%+ by HPLC analysis.
Botanical extract standardized forms are also commercially available for buyers sourcing at scale for cosmetic or nutraceutical applications. Our supply chain ensures consistent quality and compliance with international chemical distribution protocols.
Physical Properties
| Melting Point | 334.8 °C |
| Boiling Point | 346.72°C (rough estimate) |
| Density | 1.3269 (rough estimate) |
| Appearance | Yellowish Brown Solid |
| Color | Yellow to Dark Orange |
| Form | neat |
| Water Solubility | <0.1 g/100 mL at 17 ºC |
| Refractive Index | 1.4413 (estimate) |
| Log P | 4.290 (est) |
Safety & Handling (Learn More)
Trade & Regulatory
| HS Code | 29189900 |
| Storage Class | 11 - Combustible Solids |
| WGK (Germany) | 2 |
Documentation
Other Names
Monorhein|Cassic acid|Rhubarb Yellow|Rheic acid|4,5-Dihydroxyanthraquinone-2-carboxylic acid|Chrysazin-3-carboxylic acid|1,8-Dihydroxyanthraquinone-3-carboxylic acid|4,5-dihydroxy-9,10-dioxoanthracene-2-carboxylic acid
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