Isoquinoline

CAS Number
119-65-3
EC Number
204-341-8
FEMA Number
FEMA 2978

What is Isoquinoline?

Isoquinoline (CAS 119-65-3), also known commercially as leucoline, is a bicyclic nitrogen-containing aromatic compound sourced primarily from coal tar fractions.

Where is Isoquinoline used?

  • Flavoring: FEMA 2978 flavoring agent and fragrance intermediate
  • Flavor formulation: coal tar and quinoline-like nuances at trace levels in complex systems
  • Savory and roasted profiles for food products
  • Fragrance: building block for complex aroma compounds in oriental and tobacco-type compositions
  • Personal care: evaluated for preservation-enhancing properties in multi-functional formulations
  • Food-grade applications are governed by FEMA status.

Good to know: High-purity grades are required for flavor and fragrance end uses to ensure consistent sensory profiles. Documentation of permitted use is a standard procurement requirement for industrial food manufacturing and safety compliance.

Commercial specifications

  • Purities from technical to high-purity levels of 98% or higher
  • Packaging from small laboratory quantities up to drum-scale volumes

Other Names (Synonyms)

2-Benzazine|2-Azanaphthalene|Leucoline|beta-Quinoline|Benzo[c]pyridine|3,4-Benzopyridine

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What are the physical properties of Isoquinoline?

Melting Point 26.47 °C
Boiling Point 242.6-244.0 °C
Density 1.096 g/cm³ @ Temp: 204 °C
Flash Point 225 °F
Appearance LIGHT BROWN LOW MELTLING SOLID
Color Light brown
Odor at 0.10 % in triacetin. sweet balsam herbal benzaldehyde anise
Form Low Melting Solid
Water Solubility practically insoluble
Vapor Pressure 5Pa at 20℃
Refractive Index n 20/D 1.623(lit.)
pH 7.5 (5g/l, H2O, 20℃)
Log P 2.08

How is Isoquinoline classified and handled safely? Learn More

Danger
GHS06· Toxic GHS07· Irritant

Hazard Statements

H302 Harmful if swallowed
H311 Toxic in contact with skin
H315 Causes skin irritation
H319 Causes serious eye irritation
H402 Harmful to aquatic life
H412 Harmful to aquatic life with long lasting effects

Precautionary Statements

P262 Do not get in eyes, on skin, or on clothing.
P264 Wash … thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P273 Avoid release to the environment.

Which trade and regulatory codes apply to Isoquinoline?

HS Code 29334900
UN Number 2811
ADR Class 6.1
Packing Group III
WGK (Germany) 2
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