SoleChem

Guaiacol

Flavors & Fragrances Personal Care & Cosmetics
CAS
90-05-1
EC
804-496-7
Mol. Weight
124.14 g/mol

Description

Guaiacol (CAS 90-05-1), also known commercially as 2-Methoxyphenol, is a naturally derived phenolic compound obtained from wood creosote and lignin distillation. In industry, it functions as a flavoring agent and fragrance intermediate.

It also serves as a pharmaceutical precursor across multiple manufacturing sectors. In food and flavor production, it delivers the characteristic smoky, woody note found in smoked meats, whiskeys, and specialty flavor blends.

The compound carries FEMA 2532 status for use as an approved flavoring substance. Fragrance formulators use it as a building block for creating leather, tobacco, and phenolic accords in fine fragrance products.

In pharmaceutical manufacturing, it serves as a key starting material for synthesizing expectorants and other active pharmaceutical ingredients. Antioxidant and preservative applications also draw on its phenolic activity.

This activity helps to stabilize formulations against oxidative degradation. The product is supplied as a colorless to pale yellow liquid at ambient conditions, with solidification occurring near room temperature.

Standard commercial grades include food-grade material meeting FCC specifications. Pharmaceutical-grade material is also available, conforming to USP or BP standards for high-purity applications.

Technical-grade product is available for industrial synthesis and fragrance intermediate use. This versatile chemical remains a staple for manufacturers requiring consistent quality and reliable performance in diverse formulations.

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Physical Properties

Melting Point 32 °C
Boiling Point 204-206 °C
Density 1.1287 g/cm³ @ Temp: 21 °C
Flash Point 180 °F
Appearance Light Yellow Oil
Color Clear colorless to light yellow
Odor at 1.00 % in dipropylene glycol. phenolic smoke spice vanilla woody
Form Liquid After Melting
Water Solubility 17 g/L (15 ºC)
Vapor Pressure 0.11 mm Hg ( 25 °C)
Refractive Index n 20/D 1.543(lit.)
pH 5.4 (10g/l, H2O, 20℃)
Log P 1.34

Safety & Handling (Learn More)

Hazard Statements
H302 Harmful if swallowed [Warning Acute toxicity, oral]
H315 Causes skin irritation [Warning Skin corrosion/irritation]
H318 Causes serious eye damage [Danger Serious eye damage/eye irritation]
H319 Causes serious eye irritation [Warning Serious eye damage/eye irritation]
H332 Harmful if inhaled [Warning Acute toxicity, inhalation]
H336 May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]
H370 Causes damage to organs [Danger Specific target organ toxicity, single exposure]
H402 Harmful to aquatic life [Hazardous to the aquatic environment, acute hazard]
H412 Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

Trade & Regulatory

HS Code 29095010
Storage Class 11 - Combustible Solids
WGK (Germany) 1

Documentation

Other Names

2-Methoxyphenol|o-Methoxyphenol|2-Hydroxyanisole|o-Guaiacol|Guaiastil|o-Hydroxyanisole|Phenol, 2-methoxy-|Pyroguaiac acid

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