p-Cresol

CAS Number
106-44-5
EC Number
203-398-6
Chemical Formula
C7H8O
Molecular Weight
108.14 g/mol
FEMA Number
FEMA 2337

Description

p-Cresol (CAS 106-44-5), also known by its FEMA 2337 designation in flavor applications, is a methylphenol derivative used across fragrance, pharmaceutical, and industrial chemistry. It acts as a chemical building block and functional additive, serving as a precursor, preservative, and stabilizer depending on the specific formulation context and industrial requirements.

In flavors and fragrances, it contributes phenolic, smoky, and medicinal character to food flavorings and fine fragrance compositions at controlled use levels for optimal sensory profiles. Pharmaceutical manufacturers use it as an intermediate in synthesizing antioxidants, disinfectants, and active pharmaceutical ingredients, ensuring high performance in medical applications.

In coatings and polymer systems, it functions as an antioxidant stabilizer to protect resins and elastomers from oxidative degradation during processing and throughout their service life. Personal care formulators incorporate it at low concentrations for its preservative and antimicrobial properties in select cosmetic systems, maintaining product integrity and safety.

The product is supplied as a liquid or low-melting solid, depending on temperature conditions during handling. It is available in technical grade for industrial and coating applications. Higher-purity grades are available for pharmaceutical intermediate and flavor use. Packaging typically ranges from drums to ISO containers for bulk procurement and global distribution.

Other Names (Synonyms)

para-cresol|4-methylphenol

Key Technical Features

  • High Purity Grade standard
  • Consistent Batch Quality
  • Full Regulatory & REACH Support
  • Global Logistics Network enabled

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Physical Properties

Melting Point 35.5 °C
Boiling Point 201.8 °C
Density 1.0185 g/cm³ @ Temp: 40 °C
Flash Point 193 °F
Appearance Cresol is a mixture of the three isomeric cresols, o-, m-, and p-cresol. Cresols are slightly soluble in water. m-Isomer: Colorless or yellow liquid with characteristic odor.
Color Colorless to light yellow, may darken on exposure to light
Odor at 0.10 % in dipropylene glycol. phenolic narcissus animal mimosa
Form Crystalline Solid or Liquid
Water Solubility 20 g/L (20 ºC)
Vapor Pressure 1 mm Hg ( 20 °C)
Refractive Index nD20 1.5395
Log P 1.94

Documentation

Safety & Handling Learn More

Danger
GHS05· Corrosive GHS06· Toxic GHS08· Health Hazard GHS07· Irritant GHS09· Environmental Hazard

Hazard Statements

H301 Toxic if swallowed
H311 Toxic in contact with skin
H314 Causes severe skin burns and eye damage
H318 Causes serious eye damage

Precautionary Statements

P203 Obtain, consult and follow expert instructions for use.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P262 Do not get in eyes, on skin, or on clothing.

Trade & Regulatory

HS Code 29071200
UN Number 3455
ADR Class 6.1
Packing Group II
Storage Class 6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials
WGK (Germany) 1
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