Synephrine
CAS Number
94-07-5
EC Number
202-300-9
What is Synephrine?
Synephrine (CAS 94-07-5), also known as p-synephrine, is a naturally occurring alkaloid extracted primarily from bitter orange.
Where is Synephrine used?
- Pharmaceutical formulations: adrenergic agonist active ingredient
- Pharmaceutical manufacturing: active ingredient in preparations targeting nasal congestion and circulatory support
- Nutraceuticals: stimulant-adjacent botanical extract in weight management and sports nutrition products
- Topical cosmetics: skin-firming and anti-cellulite positioning in slimming creams
- Contract manufacturers source it as a pharmaceutical intermediate for synthesizing structurally related adrenergic compounds.
Good to know: Nutraceutical use is particularly common following restrictions on ephedrine-based ingredients.
Commercial specifications
- High-purity extracts standardized from Citrus aurantium
Other Names (Synonyms)
p-synephrine|p-hydroxy-alpha-[(methylamino)methyl]benzyl alcohol|beta-methylamino-alpha-(4-hydroxyphenyl)ethyl alcohol|4-hydroxy-alpha-[(methylamino)methyl]benzenemethanol|4-Hydroxy-alpha-(methylaminomethyl)benzyl alcohol|1-(4-hydroxyphenyl)-2-methylaminoethanol|Sympatol|Oxedrine
What are the physical properties of Synephrine?
Melting Point 184.5 °C
Boiling Point 341.1 °C @ Press: 760 Torr
Density 1.1222 (rough estimate)
Appearance Off-White to Beige Powder
Color White to Off-White
Form neat
Refractive Index 1.4680 (estimate)
Log P -0.450
How is Synephrine classified and handled safely? Learn More
Warning
GHS07· Irritant
Hazard Statements
H315 Causes skin irritation
H319 Causes serious eye irritation
H335 May cause respiratory irritation
Precautionary Statements
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash … thoroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
Which trade and regulatory codes apply to Synephrine?
HS Code 29225000
WGK (Germany) 3