Caffeine anhydrous

Caffeine (CAS 58-08-2) is a naturally derived alkaloid sourced primarily from coffee, tea, and guarana; also produced synthetically for industrial supply. Known in tea-based contexts as theine.

Where is Caffeine anhydrous used?

• Food and confectionery: FEMA 2224-approved flavoring agent delivering characteristic bitterness
• Pharmaceuticals: active or adjuvant ingredient in analgesic tablets
• Cold remedies and migraine formulations: enhances efficacy of co-active compounds
• Nutraceutical capsules and tablets: cognitive performance and pre-workout supplementation
• Energy drinks, sports nutrition and functional beverages: active stimulant at standardized inclusion rates
• It is found in caffeinated gummies, chocolate coatings and flavored snacks.
• Added to foods such as baked goods, ice cream, sweets, cola drinks, and energy drinks.
• Often combined with amino acids, B vitamins or plant extracts in sports products for synergistic effects.

Good to know: Standard grades include USP, BP, Ph. Eur. and food-grade; pharmaceutical grades are most commonly specified for regulated applications.

Formulation notes

• Typical single doses of 50 to 200 mg are used for the desired psychostimulant central nervous system effect.

Typical specification

• Heavy metal limits: lead ≤ 3 ppm, arsenic ≤ 2 ppm, cadmium ≤ 1 ppm, mercury ≤ 0.1 ppm.
• Microbiological limits: total plate count < 1000 CFU/g, yeast and mold < 100 CFU/g, E. coli < 10 CFU/g.
• Melting point 234.0-239.0°C according to BP/EP.
• Total impurities ≤ 0.10% according to BP/EP.

Regulatory status

• Beverages containing more than 150 mg caffeine per liter must carry the warning 'Increased caffeine content. Not recommended for children or pregnant or breast-feeding women'.
• EFSA considers a single dose of up to 200 mg caffeine safe for healthy adults.
• For food supplements, the caffeine content per recommended daily consumption amount must be stated.
• In Germany, maximum levels apply for caffeine in energy drinks: 320 mg per liter.

Storage, packaging and handling

• Stored at 10–25 °C in a dry environment.
• Keep in a tightly closed container.

Frequently asked questions about Caffeine anhydrous

What is the loss on drying for caffeine anhydrous?

Loss on drying is ≤ 0.50% according to BP/EP.

Technical content is compiled and updated by the SoleChem product team from public technical sources; the certificate of analysis (COA) governs product-specific specifications.