SoleChem

Caffeic acid

Pharmaceutical Intermediates Pharmaceuticals & Healthcare
CAS
331-39-5
EC
206-361-2
Mol. Weight
180.16 g/mol

Description

Caffeic acid (CAS 331-39-5), also known as 3,4-Dihydroxycinnamic Acid, is a hydroxycinnamic acid naturally occurring in many plants and widely sourced for use across pharmaceutical, nutraceutical, and cosmetic manufacturing.

It functions primarily as an antioxidant and UV-stabilizing agent in finished formulations. In pharmaceutical manufacturing, it serves as an intermediate in the synthesis of active compounds and is incorporated into antioxidant-focused dietary supplement formulations.

Food and beverage producers use it as a natural antioxidant to extend shelf life and protect against oxidative degradation in sensitive products. In personal care and cosmetic formulations, it is valued for its UV-stabilizing properties.

This makes it a candidate ingredient in sunscreen boosters and anti-aging topical products. Nutraceutical formulators also include it in standardized botanical extracts where polyphenol content is a defined quality parameter.

The product is supplied as a fine crystalline powder, typically off-white to light beige in color. It is available in technical and pharmaceutical-grade specifications to meet the requirements of different regulatory environments.

Purity levels of 98% and above are standard for pharmaceutical and nutraceutical applications. Documentation such as COA and HPLC testing is commonly provided to ensure compliance with global industry benchmarks.

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Physical Properties

Melting Point 225 °C (decomp)
Boiling Point 272.96°C (rough estimate)
Density 1.2933 (rough estimate)
Appearance Light yellow to greenish-yellow powder
Color yellow to tan
Form powder
Water Solubility soluble in hot water
Refractive Index 1.4500 (estimate)
Log P 1.150

Safety & Handling (Learn More)

Warning GHS07 GHS08
Hazard Statements
H315 Causes skin irritation
H319 Causes serious eye irritation
H335 May cause respiratory irritation
H351 Suspected of causing cancer
H361 Suspected of damaging fertility or the unborn child
Precautionary Statements
P203 Obtain, consult and follow expert instructions for use.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash … thoroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P318 IF exposed or concerned, get medical advice.
P319 Get medical advice/attention if you feel unwell.
P321 Specific treatment (see … on this label).
P405 Store locked up.
P501 Dispose of contents/container in accordance with local regulations.
P264+P265 Wash … thoroughly after handling.
P302+P352 IF ON SKIN: Wash with plenty of water.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P332+P317 Get emergency medical help.
P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help.
P362+P364 Take off contaminated clothing and wash it before reuse.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code 29182990
Storage Class 11 - Combustible Solids
WGK (Germany) 3

Documentation

Other Names

Cichoric acid|caffeic acid (trans from)|3,4-Dihydroxycinnamic Acid|3,4-Dihydroxy-trans-cinnamate|3,4-Dihydroxybenzeneacrylic acid|2-propenoic acid, 3-(3,4-dihydroxyphenyl)-|3-(3,4-Dihydroxyphenyl)-2-propenoic acid|(E)-3-(3,4-dihydroxyphenyl)prop-2-enoic acid

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