Duloxetine

CAS Number

116539-59-4

EC Number

601-438-0

What is Duloxetine?

Duloxetine (CAS 116539-59-4), also referenced in development literature as LY248686, is a selective serotonin-norepinephrine reuptake inhibitor (SNRI) active pharmaceutical ingredient.

Where is Duloxetine used?

Pharmaceutical manufacturing: bulk API for branded and generic prescription medications
Delayed-release oral capsules targeting major depressive disorder, generalized anxiety disorder and diabetic peripheral neuropathic pain
Enteric-coated pellet formulations that protect the compound through gastric transit
Specialty pharma: combination or modified-release formats under development
Contract manufacturers and generic drug developers procure this API.

Good to know: Procurement is subject to ICH Q7 GMP compliance; supplier qualification and documentation are central purchasing considerations. Certificates of Analysis aligned with USP and EP monograph specifications are standard.

Commercial specifications

Bulk quantities suited to commercial-scale manufacturing

Other Names (Synonyms)

(3S)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propan-1-amine|(S)-Duloxetine|Yentreve|2-Thiophenepropanamine, N-methyl-gamma-(1-naphthalenyloxy)-, (gammaS)-|(3S)-N-methyl-3-naphthalen-1-yloxy-3-thiophen-2-ylpropan-1-amine|methyl[(3S)-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propyl]amine|O5TNM5N07U

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What are the physical properties of Duloxetine?

Boiling Point 466.2±40.0 °C(Predicted)

Density 1.158±0.06 g/cm3(Predicted)

Color Light brown to yellow

Form Oil

How is Duloxetine classified and handled safely? Learn More

Warning

GHS08· Health Hazard GHS02· Flammable GHS06· Toxic

Hazard Statements

H225 Highly Flammable liquid and vapor

H301 Toxic if swallowed

H311 Toxic in contact with skin

H331 Toxic if inhaled

Precautionary Statements

P203 Obtain, consult and follow expert instructions for use.

P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.

P233 Keep container tightly closed.

P240 Ground and bond container and receiving equipment.