Memantine
CAS Number
19982-08-2
EC Number
690-724-9
Industries: Pharma & Healthcare
What is Memantine?
Memantine (CAS 19982-08-2), also known as 3,5-dimethyl-1-adamantanamine, is an active pharmaceutical ingredient used in the treatment of moderate-to-severe Alzheimer's disease.
Where is Memantine used?
- NMDA receptor antagonist; basis for branded and generic prescription drug products worldwide
- Primary active ingredient in oral tablet and solution formulations
- Starting material or advanced intermediate for synthesis of memantine hydrochloride salt, the predominant commercial form used in dosage manufacturing
- Reference standard or process intermediate for extended-release formulation development by CDMOs
- Pharmaceutical companies in regulated markets include it in combination therapies alongside cholinesterase inhibitors.
Commercial specifications
- Grades: USP, EP (Ph. Eur.), high-purity API-grade meeting ICH Q7 GMP requirements
Other Names (Synonyms)
3,5-dimethyltricyclo[3.3.1.1(3,7)]decan-1-amine|3,5-dimethyl-1-aminoadamantane|3,5-dimethyl-1-adamantanamine|1,3-dimethylaminoadamantane|1,3-dimethyl-5-adamantanamine|1-amino-3,5-dimethyladamantane|3,5-dimethyladamantan-1-amine|Memantina
What are the physical properties of Memantine?
Melting Point 258 °C
Boiling Point 239.8±8.0 °C(Predicted)
Density 1.046
Color Colorless Oil to Off-White Waxy
Form Solid
Refractive Index nD25 1.4941
How is Memantine classified and handled safely? Learn More
Warning
GHS07· Irritant
Hazard Statements
H302 Harmful if swallowed
Precautionary Statements
P264 Wash … thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P330 Rinse mouth.
P501 Dispose of contents/container in accordance with local regulations.
P301+P317 Get emergency medical help.